U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ep300 E1A binding protein p300 [ Mus musculus (house mouse) ]

    Gene ID: 328572, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ep300provided by MGI
    Official Full Name
    E1A binding protein p300provided by MGI
    Primary source
    MGI:MGI:1276116
    See related
    Ensembl:ENSMUSG00000055024 AllianceGenome:MGI:1276116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p300; KAT3B; p300 HAT; A430090G16; A730011L11
    Summary
    Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; protein acylation; and protein stabilization. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and somitogenesis. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; eye; heart; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 16.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ep300 in Genome Data Viewer
    Location:
    15 E1; 15 38.16 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81470329..81536273)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81586209..81652077)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7397 Neighboring gene STARR-positive B cell enhancer ABC_E10870 Neighboring gene STARR-positive B cell enhancer ABC_E5497 Neighboring gene ring-box 1 Neighboring gene STARR-seq mESC enhancer starr_39256 Neighboring gene STARR-seq mESC enhancer starr_39257 Neighboring gene predicted gene 5218 Neighboring gene STARR-seq mESC enhancer starr_39258 Neighboring gene STARR-seq mESC enhancer starr_39259 Neighboring gene RIKEN cDNA 1110025M09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1914 Neighboring gene predicted gene, 22067 Neighboring gene STARR-positive B cell enhancer ABC_E2446 Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene chondroadherin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables STAT family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylation-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K122 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K122 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K18 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K27 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 propionyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables histone butyryltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone crotonyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone crotonyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone lactyltransferase (CoA-dependent) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone lactyltransferase (CoA-dependent) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear androgen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide 2-hydroxyisobutyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide butyryltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein propionyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein propionyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in N-terminal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in N-terminal peptidyl-lysine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in behavioral defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cartilage development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-leucine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in internal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in internal protein amino acid acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine butyrylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine butyrylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine crotonylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine crotonylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-lysine propionylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine propionylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within platelet formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of T-helper 17 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of TORC2 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-DNA complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiotensin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in swimming IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thigmotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase p300
    Names
    E1A-associated protein p300
    histone butyryltransferase p300
    histone crotonyltransferase p300
    protein 2-hydroxyisobutyryltransferase p300
    protein lactyltransferas p300
    protein propionyltransferase p300
    NP_808489.4
    XP_006521152.1
    XP_006521153.1
    XP_006521154.1
    XP_030104471.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177821.7NP_808489.4  histone acetyltransferase p300

      See identical proteins and their annotated locations for NP_808489.4

      Status: VALIDATED

      Source sequence(s)
      AC102262, AC160528
      Consensus CDS
      CCDS37149.1
      UniProtKB/Swiss-Prot
      B2RWS6, E9PYJ8
      Related
      ENSMUSP00000066789.5, ENSMUST00000068387.11
      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      TIGR01628
      Location:714848
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00551
      Location:17281806
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16671707
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691241
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12421276
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam07133
      Location:9591048
      Merozoite_SPAM; Merozoite surface protein (SPAM)
      pfam09606
      Location:19582334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:348415
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:567647
      KIX; KIX domain
      pfam08214
      Location:13051516
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20062099
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81470329..81536273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521089.3XP_006521152.1  histone acetyltransferase p300 isoform X1

      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      TIGR01628
      Location:714848
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00551
      Location:17381816
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16771717
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691251
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12521286
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam07133
      Location:9591048
      Merozoite_SPAM; Merozoite surface protein (SPAM)
      pfam09606
      Location:19682344
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:348415
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:567647
      KIX; KIX domain
      pfam08214
      Location:13151526
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20162109
      Creb_binding; Creb binding
    2. XM_006521090.4XP_006521153.1  histone acetyltransferase p300 isoform X2

      Conserved Domains (12) summary
      cd05495
      Location:10501150
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      TIGR01628
      Location:714848
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00551
      Location:17311809
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16701710
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11621244
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12451279
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam07133
      Location:9591048
      Merozoite_SPAM; Merozoite surface protein (SPAM)
      pfam09606
      Location:19612337
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:348415
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:567647
      KIX; KIX domain
      pfam08214
      Location:13081519
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20092102
      Creb_binding; Creb binding
    3. XM_030248611.2XP_030104471.1  histone acetyltransferase p300 isoform X3

      Conserved Domains (12) summary
      cd05495
      Location:10501150
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      TIGR01628
      Location:714848
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00551
      Location:17211799
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16601700
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11621234
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12351269
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam07133
      Location:9591048
      Merozoite_SPAM; Merozoite surface protein (SPAM)
      pfam09606
      Location:19512327
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:348415
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:567647
      KIX; KIX domain
      pfam08214
      Location:12981509
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19992092
      Creb_binding; Creb binding
    4. XM_006521091.4XP_006521154.1  histone acetyltransferase p300 isoform X4

      Conserved Domains (12) summary
      cd05495
      Location:10041111
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      TIGR01628
      Location:668802
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00551
      Location:16921770
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16311671
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11231205
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12061240
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam07133
      Location:9131002
      Merozoite_SPAM; Merozoite surface protein (SPAM)
      pfam09606
      Location:19222298
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:348415
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:543601
      KIX; KIX domain
      pfam08214
      Location:12691480
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19702063
      Creb_binding; Creb binding