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    Arfgef3 ARFGEF family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 215821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arfgef3provided by MGI
    Official Full Name
    ARFGEF family member 3provided by MGI
    Primary source
    MGI:MGI:106387
    See related
    Ensembl:ENSMUSG00000019852 AllianceGenome:MGI:106387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIG3; mKIAA1244; 9630004D11; D10Bwg1379e; B930094H20Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in Golgi apparatus and transport vesicle membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human ARFGEF3 (ARFGEF family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 3.5), colon adult (RPKM 3.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arfgef3 in Genome Data Viewer
    Location:
    10 A3; 10 7.79 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18463759..18619506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (18588011..18743758, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene NHS like 1 Neighboring gene STARR-seq mESC enhancer starr_25897 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_25901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18228522-18228723 Neighboring gene STARR-seq mESC enhancer starr_25912 Neighboring gene heme binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_25915 Neighboring gene STARR-seq mESC enhancer starr_25916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18384699-18384900 Neighboring gene predicted gene, 32926 Neighboring gene STARR-seq mESC enhancer starr_25918 Neighboring gene RIKEN cDNA 4930444F02 gene Neighboring gene predicted gene 4922

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice. Li H, et al. Mol Metab, 2015 Mar. PMID 25737957, Free PMC Article
    2. Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons. Liu T, et al. J Neurochem, 2016 Dec. PMID 27696409
    3. Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. Liu T, et al. Am J Physiol Endocrinol Metab, 2014 Oct 1. PMID 25139048
    4. BIG3 inhibits insulin granule biogenesis and insulin secretion. Li H, et al. EMBO Rep, 2014 Jun. PMID 24711543, Free PMC Article
    5. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033258.4 → NP_001028430.1  brefeldin A-inhibited guanine nucleotide-exchange protein 3

      See identical proteins and their annotated locations for NP_001028430.1

      Status: PROVISIONAL

      Source sequence(s)
      AC153558, AC153561
      Consensus CDS
      CCDS23712.1
      UniProtKB/Swiss-Prot
      Q3UGY8, Q80TH0
      Related
      ENSMUSP00000149210.2, ENSMUST00000215836.2
      Conserved Domains (3) summary
      smart00222
      Location:582 → 794
      Sec7; Sec7 domain
      pfam09324
      Location:1241 → 1298
      DUF1981; Domain of unknown function (DUF1981)
      pfam16213
      Location:16 → 121
      DCB; dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      18463759..18619506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UGY8.1 GenPept UniProtKB/Swiss-Prot:Q3UGY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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