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    Taf4b TATA-box binding protein associated factor 4b [ Mus musculus (house mouse) ]

    Gene ID: 72504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taf4bprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor 4bprovided by MGI
    Primary source
    MGI:MGI:2152345
    See related
    Ensembl:ENSMUSG00000054321 AllianceGenome:MGI:2152345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    105kDa; Taf2c2; TAFII105; TAFII-105; 2610524B04Rik; 4932409F03Rik
    Summary
    Predicted to enable DNA binding activity and NF-kappaB binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of stem cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in genitourinary system and tail. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 3.7), testis adult (RPKM 2.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taf4b in Genome Data Viewer
    Location:
    18 A1; 18 8.28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (14916302..15035160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (14783201..14960424)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SS18, subunit of BAF chromatin remodeling complex Neighboring gene predicted gene, 24924 Neighboring gene STARR-seq mESC enhancer starr_43875 Neighboring gene STARR-seq mESC enhancer starr_43877 Neighboring gene proteasome subunit alpha 8 Neighboring gene STARR-positive B cell enhancer ABC_E1951 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_43878 Neighboring gene RIKEN cDNA 4930543D07 gene Neighboring gene SUMO/sentrin specific peptidase 5 pseudogene Neighboring gene predicted gene, 54035

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 4B
    Names
    TAF(II)105
    TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
    transcription initiation factor TFIID 105 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100449.2NP_001093919.1  transcription initiation factor TFIID subunit 4B isoform 1

      See identical proteins and their annotated locations for NP_001093919.1

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      Consensus CDS
      CCDS50227.1
      UniProtKB/Swiss-Prot
      G5E8Z2
      UniProtKB/TrEMBL
      A0A3B2W725
      Related
      ENSMUSP00000126909.2, ENSMUST00000169862.2
      Conserved Domains (2) summary
      pfam05236
      Location:610850
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:257343
      TAFH; NHR1 homology to TAF
    2. NM_001369357.1NP_001356286.1  transcription initiation factor TFIID subunit 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      Consensus CDS
      CCDS89195.1
      UniProtKB/Swiss-Prot
      G5E8Z2
      UniProtKB/TrEMBL
      A0A3Q4EGS4
      Related
      ENSMUSP00000157354.2, ENSMUST00000234789.2
      Conserved Domains (3) summary
      PRK14950
      Location:291
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam05236
      Location:605845
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:257343
      TAFH; NHR1 homology to TAF
    3. NM_001369358.1NP_001356287.1  transcription initiation factor TFIID subunit 4B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      UniProtKB/Swiss-Prot
      G5E8Z2
      Conserved Domains (4) summary
      COG5665
      Location:137318
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      PRK14950
      Location:291
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam05236
      Location:564804
      TAF4; Transcription initiation factor TFIID component TAF4 family
      cl02658
      Location:253302
      TAFH; NHR1 homology to TAF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      14916302..15035160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)