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    Trpc2 transient receptor potential cation channel, subfamily C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22064, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trpc2provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 2provided by MGI
    Primary source
    MGI:MGI:109527
    See related
    Ensembl:ENSMUSG00000100254 AllianceGenome:MGI:109527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    trp2; Trrp2; mTrp2; TRPC2a; TRPC2b; smTRPC2; 3010009O07Rik
    Summary
    Enables diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Acts upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Located in dendrite membrane and endomembrane system. Is expressed in brain; ganglia; genitourinary system; sensory organ; and skeletal muscle. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
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    Genomic context

    See Trpc2 in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101732323..101746071)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102083116..102096864)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Xntrpc

    Readthrough gene: Xntrpc, Included gene: Xndc1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables store-operated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables store-operated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mating behavior, sex discrimination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of male mating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in single strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within territorial aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    short transient receptor potential channel 2
    Names
    transient receptor potential 2-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109897.2NP_001103367.1  short transient receptor potential channel 2

      Status: VALIDATED

      Source sequence(s)
      AC132297, AC150275
      Consensus CDS
      CCDS52333.1
      UniProtKB/Swiss-Prot
      Q9R244
      Related
      ENSMUSP00000116934.3, ENSMUST00000124189.3
      Conserved Domains (4) summary
      cd00204
      Location:63172
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:23761
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:183242
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:93138
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101732323..101746071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)