Tef thyrotroph embryonic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tefprovided by MGI
Official Full Name: thyrotroph embryonic factorprovided by MGI
Primary source: MGI:MGI:98663
See related: Ensembl:ENSMUSG00000022389 AllianceGenome:MGI:98663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310028D20Rik
Summary: Enables double-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; early conceptus; genitourinary system; and trunk somite. Orthologous to human TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 46.8), bladder adult (RPKM 43.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.25 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81686874..81711064)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81802673..81826863)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of TEF expression significantly retarded Bladder Cancer cell growth by inhibiting the G1/S transition via regulating AKT/FOXOs signalling.
Title: Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway.
In Ccdc80(-/-) mice, expression of the core clock member Arntl/Bmal1 was reduced whereas that of the oscillating transcription factors Dbp and Tef was increased in all tissues examined.
Title: Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
evidence of TEF regulation through a miR-125b-mediated pathway
Title: A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts.
Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group.
Title: Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
Title: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
Title: Molecular clock is involved in predictive circadian adjustment of renal function.
mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain
Title: The loss of circadian PAR bZip transcription factors results in epilepsy.
TEF contributes to the activation of the telokin promoter in smooth muscle cells in a calcium-dependent manner
Title: Activation of the smooth muscle-specific telokin gene by thyrotroph embryonic factor (TEF).
The Tef protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
Title: The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyrotroph embryonic factor

Names: thyrotrophic embryonic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017376.3 → NP_059072.1 thyrotroph embryonic factor isoform 1

See identical proteins and their annotated locations for NP_059072.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK147965, AY540631, BP764162, BY336350

Consensus CDS

CCDS27672.1

UniProtKB/Swiss-Prot

Q3U426, Q3UGF4, Q3UM49, Q3URC8, Q6QHT6, Q8C6I0, Q8VD02, Q9JLC6

UniProtKB/TrEMBL

Q3V3B6

Related

ENSMUSP00000023024.8, ENSMUST00000023024.8

Conserved Domains (1) summary

cd14695
Location:230 → 288

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
NM_153484.3 → NP_705617.2 thyrotroph embryonic factor isoform 2

See identical proteins and their annotated locations for NP_705617.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' coding exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK141606, AK147965, BP764162, BY296040

Consensus CDS

CCDS27671.2

UniProtKB/TrEMBL

Q3V3B6

Related

ENSMUSP00000105180.3, ENSMUST00000109553.10

Conserved Domains (1) summary

cd14695
Location:214 → 272

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

81686874..81711064

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245558.4 → XP_011243860.1 thyrotroph embryonic factor isoform X2

See identical proteins and their annotated locations for XP_011243860.1

UniProtKB/TrEMBL

Q3V3B6

Conserved Domains (1) summary

cd14695
Location:253 → 311

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_011245557.4 → XP_011243859.1 thyrotroph embryonic factor isoform X1

Conserved Domains (1) summary

cd14695
Location:269 → 327

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_011245560.3 → XP_011243862.1 thyrotroph embryonic factor isoform X3

See identical proteins and their annotated locations for XP_011243862.1

UniProtKB/TrEMBL

Q3V3B6

Conserved Domains (1) summary

cd14695
Location:200 → 258

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_006520744.2 → XP_006520807.1 thyrotroph embryonic factor isoform X4

UniProtKB/TrEMBL

Q3V3B6

Conserved Domains (1) summary

cd14695
Location:161 → 219

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_036159316.1 → XP_036015209.1 thyrotroph embryonic factor isoform X6

Conserved Domains (1) summary

cd14695
Location:110 → 168

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_030248461.2 → XP_030104321.1 thyrotroph embryonic factor isoform X6

Conserved Domains (1) summary

cd14695
Location:110 → 168

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_011245559.3 → XP_011243861.1 thyrotroph embryonic factor isoform X3

See identical proteins and their annotated locations for XP_011243861.1

UniProtKB/TrEMBL

Q3V3B6

Conserved Domains (1) summary

cd14695
Location:200 → 258

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_030248460.2 → XP_030104320.1 thyrotroph embryonic factor isoform X4

UniProtKB/TrEMBL

Q3V3B6

Conserved Domains (1) summary

cd14695
Location:161 → 219

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
XM_036159315.1 → XP_036015208.1 thyrotroph embryonic factor isoform X5

Conserved Domains (1) summary

cd14695
Location:119 → 177

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain