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    Hhip Hedgehog-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 15245, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hhipprovided by MGI
    Official Full Name
    Hedgehog-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1341847
    See related
    Ensembl:ENSMUSG00000064325 AllianceGenome:MGI:1341847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hhip1
    Summary
    Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of smoothened signaling pathway and skeletal system morphogenesis. Acts upstream of or within several processes, including epithelial tube branching involved in lung morphogenesis; neuroblast proliferation; and regulation of fibroblast growth factor receptor signaling pathway. Located in cell surface and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 4.5), lung adult (RPKM 2.4) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hhip in Genome Data Viewer
    Location:
    8 C2; 8 37.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80692480..80784637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79965850..80058060, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 10 Neighboring gene STARR-seq mESC enhancer starr_22022 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494 Neighboring gene STARR-seq mESC enhancer starr_22024 Neighboring gene STARR-seq mESC enhancer starr_22025 Neighboring gene STARR-seq mESC enhancer starr_22026 Neighboring gene predicted gene, 39206 Neighboring gene Hhip1 peak 1 Gli-inducible enhancer Neighboring gene predicted gene, 53441 Neighboring gene STARR-seq mESC enhancer starr_22028 Neighboring gene zinc finger CCCH-type containing 15 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hedgehog family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hedgehog family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hedgehog-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424822.1NP_001411751.1  hedgehog-interacting protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC109146, AC163438
    2. NM_020259.4NP_064655.4  hedgehog-interacting protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_064655.4

      Status: VALIDATED

      Source sequence(s)
      AC109146, AK031841, AW121326, BC053012, BY142826, CV561558
      Consensus CDS
      CCDS22440.1
      UniProtKB/Swiss-Prot
      Q7TN16, Q8C0B0, Q9WU59
      Related
      ENSMUSP00000078047.3, ENSMUST00000079038.4
      Conserved Domains (2) summary
      pfam03024
      Location:38220
      Folate_rec; Folate receptor family
      pfam07995
      Location:226428
      GSDH; Glucose / Sorbosone dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      80692480..80784637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)