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    Gja1 gap junction protein, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 14609, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gja1provided by MGI
    Official Full Name
    gap junction protein, alpha 1provided by MGI
    Primary source
    MGI:MGI:95713
    See related
    Ensembl:ENSMUSG00000050953 AllianceGenome:MGI:95713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cx43; Npm1; Cnx43; Cxnk1; Gja-1; Cx43alpha1; connexin43
    Summary
    Enables several functions, including beta-tubulin binding activity; glutathione transmembrane transporter activity; and scaffold protein binding activity. Involved in several processes, including cellular response to amyloid-beta; glutamate secretion; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell communication by chemical coupling; circulatory system development; and regulation of gene expression. Located in several cellular components, including fascia adherens; gap junction; and lateral plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart and pericardium; and sensory organ. Used to study oculodentodigital dysplasia. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); erythrokeratodermia variabilis (multiple); hypoplastic left heart syndrome; oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 68.8), heart adult (RPKM 61.3) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gja1 in Genome Data Viewer
    Location:
    10 B4; 10 28.64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (56253297..56266519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (56377300..56390419)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 32 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55826518-55826701 Neighboring gene MSL3 like 2 Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene STARR-positive B cell enhancer ABC_E8334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55948756-55948865 Neighboring gene STARR-seq mESC enhancer starr_26724 Neighboring gene STARR-seq mESC enhancer starr_26725 Neighboring gene STARR-seq mESC enhancer starr_26726 Neighboring gene STARR-seq mESC enhancer starr_26730 Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_26731 Neighboring gene STARR-seq mESC enhancer starr_26732 Neighboring gene STARR-seq mESC enhancer starr_26734 Neighboring gene predicted gene, 36460 Neighboring gene predicted gene, 36517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables connexin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables connexin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables gap junction channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables gap junction channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gap junction channel activity involved in cardiac conduction electrical coupling TAS
    Traceable Author Statement
    more info
    PubMed 
    enables gap junction channel activity involved in cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    enables gap junction hemi-channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutathione transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoatomic ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ATP transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within atrial ventricular junction remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell communication by chemical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell communication by electrical coupling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell communication by electrical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell communication by electrical coupling involved in cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelium development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epicardial cell to mesenchymal cell transition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epididymis development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of epithelial cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of protein localization in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein localization in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within milk ejection reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gonadotropin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gonadotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell communication by chemical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell communication by chemical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of Sertoli cell barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of establishment of Sertoli cell barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood vessel remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell communication by electrical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of connexin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of connexin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in contractile muscle fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gap junction alpha-1 protein
    Names
    alpha 1 connexin
    connexin k1
    connexin-43
    gap junction 43 kDa heart protein
    gap junction membrane channel protein alpha 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428498.1NP_001415427.1  gap junction alpha-1 protein

      Status: VALIDATED

      Source sequence(s)
      AC152949
      UniProtKB/Swiss-Prot
      P23242, Q544I7, Q8CE05
      UniProtKB/TrEMBL
      A0A654ICD2, Q7TMQ1
    2. NM_001428499.1NP_001415428.1  gap junction alpha-1 protein

      Status: VALIDATED

      Source sequence(s)
      AC152949
      UniProtKB/Swiss-Prot
      P23242, Q544I7, Q8CE05
      UniProtKB/TrEMBL
      A0A654ICD2, Q7TMQ1
    3. NM_001428500.1NP_001415429.1  gap junction alpha-1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AC152949
      UniProtKB/Swiss-Prot
      P23242, Q544I7, Q8CE05
      UniProtKB/TrEMBL
      A0A654ICD2, Q7TMQ1
    4. NM_001428501.1NP_001415430.1  gap junction alpha-1 protein

      Status: VALIDATED

      Source sequence(s)
      AC152949
      UniProtKB/Swiss-Prot
      P23242, Q544I7, Q8CE05
      UniProtKB/TrEMBL
      A0A654ICD2, Q7TMQ1
    5. NM_010288.4NP_034418.1  gap junction alpha-1 protein

      See identical proteins and their annotated locations for NP_034418.1

      Status: VALIDATED

      Source sequence(s)
      AC152949
      Consensus CDS
      CCDS23851.1
      UniProtKB/Swiss-Prot
      P23242, Q544I7, Q8CE05
      UniProtKB/TrEMBL
      A0A654ICD2, Q7TMQ1
      Related
      ENSMUSP00000064536.8, ENSMUST00000068581.9
      Conserved Domains (2) summary
      pfam00029
      Location:3233
      Connexin
      pfam03508
      Location:293312
      Connexin43; Gap junction alpha-1 protein (Cx43)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      56253297..56266519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155617.1XP_036011510.1  gap junction alpha-1 protein isoform X1

      Related
      ENSMUSP00000151620.2, ENSMUST00000220069.2
      Conserved Domains (2) summary
      pfam00029
      Location:3233
      Connexin
      pfam03508
      Location:293312
      Connexin43; Gap junction alpha-1 protein (Cx43)