U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ncbp3 nuclear cap binding subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 66874, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ncbp3provided by MGI
    Official Full Name
    nuclear cap binding subunit 3provided by MGI
    Primary source
    MGI:MGI:1914124
    See related
    Ensembl:ENSMUSG00000020783 AllianceGenome:MGI:1914124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200014J11Rik; C130061O14Rik
    Summary
    Enables RNA cap binding activity. Predicted to be involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human NCBP3 (nuclear cap binding subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.2), CNS E14 (RPKM 3.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ncbp3 in Genome Data Viewer
    Location:
    11 B4; 11 45.16 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72937443..72974405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73047867..73083579)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA 7-methylguanosine cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in snRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear cap-binding protein subunit 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025818.3NP_080094.3  nuclear cap-binding protein subunit 3

      See identical proteins and their annotated locations for NP_080094.3

      Status: VALIDATED

      Source sequence(s)
      AK081659, AK153241, AL670399, CJ093775, CN666791
      Consensus CDS
      CCDS24994.1
      UniProtKB/Swiss-Prot
      Q3TNF4, Q3TQ96, Q4G0C3, Q8BMB1, Q8BZR9, Q9CRM6, Q9CS93, Q9D0G9, Q9DBT0
      UniProtKB/TrEMBL
      Q7TPS9
      Related
      ENSMUSP00000021135.4, ENSMUST00000021135.5
      Conserved Domains (1) summary
      pfam10309
      Location:123177
      DUF2414; Protein of unknown function (DUF2414)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72937443..72974405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156901.1XP_036012794.1  nuclear cap-binding protein subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam10309
      Location:123177
      NCBP3; Nuclear cap-binding protein subunit 3