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    Scrn1 secernin 1 [ Mus musculus (house mouse) ]

    Gene ID: 69938, updated on 3-Dec-2024

    Summary

    Official Symbol
    Scrn1provided by MGI
    Official Full Name
    secernin 1provided by MGI
    Primary source
    MGI:MGI:1917188
    See related
    Ensembl:ENSMUSG00000019124 AllianceGenome:MGI:1917188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SES1; mKIAA0193; 2810019K23Rik; 6330535A03Rik
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in exocytosis and regulation of synaptic vesicle cycle. Predicted to be located in nuclear membrane. Predicted to be active in presynapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system ganglion; reproductive system; and retina. Orthologous to human SCRN1 (secernin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 16.2), frontal lobe adult (RPKM 12.4) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Scrn1 in Genome Data Viewer
    Location:
    6 B3; 6 26.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54451813..54543332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54474794..54566517, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene proline rich 15 Neighboring gene predicted gene, 34169 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene predicted gene, 52863 Neighboring gene FK506 binding protein 14 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene predicted gene, 34249

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417702.1NP_001404631.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8
    2. NM_001417703.1NP_001404632.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8
    3. NM_001417704.1NP_001404633.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8
    4. NM_001417705.1NP_001404634.1  secernin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC087841
      UniProtKB/TrEMBL
      A0A0N4SWD0
    5. NM_001417706.1NP_001404635.1  secernin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC087841
      UniProtKB/TrEMBL
      A0A0N4SWD0
      Related
      ENSMUSP00000145469.2, ENSMUST00000203800.2
    6. NM_027268.3NP_081544.1  secernin-1 isoform a

      See identical proteins and their annotated locations for NP_081544.1

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      Consensus CDS
      CCDS20156.1
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8
      Related
      ENSMUSP00000019268.5, ENSMUST00000019268.11
      Conserved Domains (1) summary
      cl00467
      Location:18227
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54451813..54543332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)