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    Ntn4 netrin 4 [ Mus musculus (house mouse) ]

    Gene ID: 57764, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ntn4provided by MGI
    Official Full Name
    netrin 4provided by MGI
    Primary source
    MGI:MGI:1888978
    See related
    Ensembl:ENSMUSG00000020019 AllianceGenome:MGI:1888978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables laminin-1 binding activity. Acts upstream of or within neuron remodeling and regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; connective tissue; genitourinary system; and nervous system. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 32.3), kidney adult (RPKM 17.5) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10 C2; 10 48.59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93476911..93581834)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93641049..93745972)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8360 Neighboring gene STARR-seq mESC enhancer starr_27586 Neighboring gene coiled-coil domain containing 38 Neighboring gene STARR-positive B cell enhancer ABC_E6903 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6904 Neighboring gene STARR-positive B cell enhancer ABC_E9800 Neighboring gene small nuclear ribonucleoprotein polypeptide F Neighboring gene STARR-seq mESC enhancer starr_27587 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene predicted gene 15915 Neighboring gene STARR-seq mESC enhancer starr_27589 Neighboring gene STARR-seq mESC enhancer starr_27590 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 26239

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables laminin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021320.3NP_067295.2  netrin-4 precursor

      See identical proteins and their annotated locations for NP_067295.2

      Status: VALIDATED

      Source sequence(s)
      AC151976, BB609851, BC119182, CF537120, CJ068258, CX205916
      Consensus CDS
      CCDS24128.1
      UniProtKB/Swiss-Prot
      E9QMT3, Q9JI33
      UniProtKB/TrEMBL
      Q0VEM1
      Related
      ENSMUSP00000020204.5, ENSMUST00000020204.5
      Conserved Domains (4) summary
      cd00055
      Location:261320
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03578
      Location:517626
      NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
      pfam00053
      Location:395449
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:43260
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93476911..93581834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)