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    Rbx1 ring-box 1 [ Mus musculus (house mouse) ]

    Gene ID: 56438, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbx1provided by MGI
    Official Full Name
    ring-box 1provided by MGI
    Primary source
    MGI:MGI:1891829
    See related
    Ensembl:ENSMUSG00000022400 AllianceGenome:MGI:1891829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ROC1; 1500002P15Rik
    Summary
    Predicted to enable several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; and protein ubiquitination. Acts upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Located in cytosol. Part of Cul4A-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 40.8) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbx1 in Genome Data Viewer
    Location:
    15 E1; 15 38.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81350517..81360570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81466316..81476369)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025 Neighboring gene STARR-positive B cell enhancer ABC_E7397 Neighboring gene STARR-positive B cell enhancer ABC_E10870 Neighboring gene STARR-positive B cell enhancer ABC_E5497 Neighboring gene STARR-seq mESC enhancer starr_39256 Neighboring gene STARR-seq mESC enhancer starr_39257 Neighboring gene predicted gene 5218 Neighboring gene STARR-seq mESC enhancer starr_39258 Neighboring gene STARR-seq mESC enhancer starr_39259 Neighboring gene RIKEN cDNA 1110025M09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1914 Neighboring gene E1A binding protein p300

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NEDD8 ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NEDD8 ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic initiation factor 4E binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein monoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex EXP
    Inferred from Experiment
    more info
    PubMed 
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Cul4B-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4B-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Cul5-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul7-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul7-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    Names
    E3 ubiquitin-protein transferase RBX1
    RING finger protein 75
    ring-box protein 1
    NP_062686.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019712.3NP_062686.1  E3 ubiquitin-protein ligase RBX1

      Status: VALIDATED

      Source sequence(s)
      BB807275, BC056992, CB522825, CJ082632
      Consensus CDS
      CCDS49676.1
      UniProtKB/Swiss-Prot
      P62878
      Related
      ENSMUSP00000023036.6, ENSMUST00000023036.7
      Conserved Domains (1) summary
      cd16485
      Location:40101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81350517..81360570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)