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    Letmd1 LETM1 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Letmd1provided by MGI
    Official Full Name
    LETM1 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915864
    See related
    Ensembl:ENSMUSG00000037353 AllianceGenome:MGI:1915864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mccr; HCCR1; HCCR-2; MCC-32; 1110019O13Rik
    Summary
    Enables molecular adaptor activity. Involved in mitochondrion organization and positive regulation of cold-induced thermogenesis. Located in mitochondrial inner membrane. Is active in nucleus. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; and retina. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.3), mammary gland adult (RPKM 24.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Letmd1 in Genome Data Viewer
    Location:
    15 F1; 15 56.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100360302..100377133)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100462421..100479252)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4149 Neighboring gene RIKEN cDNA 5330439K02 gene Neighboring gene predicted gene 5475 Neighboring gene STARR-positive B cell enhancer mm9_chr15:100274003-100274304 Neighboring gene STARR-seq mESC enhancer starr_39750 Neighboring gene STARR-seq mESC enhancer starr_39751 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes. Snyder MM, et al. FASEB J, 2021 Nov. PMID 34669999
    2. Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue. Song R, et al. Biochimie, 2022 Oct. PMID 35817133
    3. [(18)F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue. Levi J, et al. Commun Biol, 2024 Jul 1. PMID 38951146, Free PMC Article
    4. The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression. Cho GW, et al. Gene, 2006 Dec 15. PMID 16949218
    5. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages. Lim SG, et al. J Immunol, 2020 Mar 1. PMID 31980577

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
      Title: LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
    2. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.
      Title: Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.
    3. Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue.
      Title: Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue.
    4. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.
      Title: Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.
    5. LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes.
      Title: LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes.
    6. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages.
      Title: LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages.
    7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE
      Title: Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity.
    8. The level of HCCR-1 expression was increased during the mouse embryogenesis and expression of phosphatidylinositol 3-kinase (PI3K) in NIH/3T3 cells activated the HCCR-1 promoter.
      Title: The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LETM1 domain-containing protein 1
    Names
    cervical cancer receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357982.1 → NP_001344911.1  LETM1 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC139571
      Consensus CDS
      CCDS88845.1
      Related
      ENSMUSP00000155807.2, ENSMUST00000230294.2
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    2. NM_001357983.1 → NP_001344912.1  LETM1 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC139571
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 254
      LETM1; LETM1-like protein

    3. NM_001357984.1 → NP_001344913.1  LETM1 domain-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC139571
      Consensus CDS
      CCDS88844.1
      Related
      ENSMUSP00000155084.2, ENSMUST00000229648.2
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 256
      LETM1; LETM1-like protein

    4. NM_134093.3 → NP_598854.1  LETM1 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_598854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC139571
      Consensus CDS
      CCDS27838.1
      UniProtKB/Swiss-Prot
      Q3TF05, Q3U3M7, Q8BLG9, Q8K1F7, Q8VDS9, Q924L1
      Related
      ENSMUSP00000037546.9, ENSMUST00000037001.10
      Conserved Domains (1) summary
      pfam07766
      Location:80 → 338
      LETM1; LETM1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100360302..100377133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316739.2 → XP_017172228.1  LETM1 domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q924L1
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    2. XM_006521322.3 → XP_006521385.1  LETM1 domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006521385.1

      UniProtKB/Swiss-Prot
      Q924L1
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    3. XM_036159561.1 → XP_036015454.1  LETM1 domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam07766
      Location:1 → 186
      LETM1; LETM1-like protein

    4. XM_036159562.1 → XP_036015455.1  LETM1 domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam07766
      Location:1 → 186
      LETM1; LETM1-like protein

    5. XM_030248726.2 → XP_030104586.1  LETM1 domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      pfam07766
      Location:116 → 244
      LETM1; LETM1-like protein

    6. XM_006521320.4 → XP_006521383.1  LETM1 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:79 → 343
      LETM1; LETM1-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924L1.1 GenPept UniProtKB/Swiss-Prot:Q924L1

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