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    Meis1 Meis homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 17268, updated on 9-Dec-2024

    Summary

    Official Symbol
    Meis1provided by MGI
    Official Full Name
    Meis homeobox 1provided by MGI
    Primary source
    MGI:MGI:104717
    See related
    Ensembl:ENSMUSG00000020160 AllianceGenome:MGI:104717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi8; C530044H18Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study restless legs syndrome. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 25.6), CNS E11.5 (RPKM 9.3) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Meis1 in Genome Data Viewer
    Location:
    11 A3.1; 11 11.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (18830428..18968992, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (18880428..19019651, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31674 Neighboring gene predicted gene, 23021 Neighboring gene RIKEN cDNA 8430419K02 gene Neighboring gene STARR-seq mESC enhancer starr_28733 Neighboring gene STARR-seq mESC enhancer starr_28735 Neighboring gene STARR-seq mESC enhancer starr_28736 Neighboring gene predicted gene 16141 Neighboring gene RIKEN cDNA 4933406G16 gene Neighboring gene STARR-seq mESC enhancer starr_28738 Neighboring gene STARR-seq mESC enhancer starr_28739 Neighboring gene STARR-seq mESC enhancer starr_28740 Neighboring gene predicted gene, 53669

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Meis1
    Names
    myeloid ecotropic viral integration site 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193271.1NP_001180200.1  homeobox protein Meis1 isoform B

      See identical proteins and their annotated locations for NP_001180200.1

      Status: VALIDATED

      Description
      Transcript Variant: : This variant (B) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) has a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK140748, AL645570
      Consensus CDS
      CCDS56760.1
      UniProtKB/Swiss-Prot
      B1ARH5, Q5SVC8, Q60954, Q60955, Q8CIL0
      UniProtKB/TrEMBL
      H3BLB6
      Related
      ENSMUSP00000069277.8, ENSMUST00000068264.14
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. NM_010789.3NP_034919.1  homeobox protein Meis1 isoform A

      See identical proteins and their annotated locations for NP_034919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AL603984, AL645570
      Consensus CDS
      CCDS24453.1
      UniProtKB/TrEMBL
      H3BLB6
      Related
      ENSMUSP00000139219.2, ENSMUST00000185131.8
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      18830428..18968992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314312.3XP_017169801.1  homeobox protein Meis1 isoform X2

      UniProtKB/TrEMBL
      H3BLB6
      Conserved Domains (2) summary
      pfam05920
      Location:241280
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108161
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. XM_006514559.5XP_006514622.1  homeobox protein Meis1 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:277408
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05920
      Location:241280
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108161
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    3. XM_030245628.2XP_030101488.1  homeobox protein Meis1 isoform X3

      UniProtKB/TrEMBL
      Q3UJ00
      Related
      ENSMUST00000118661.8
      Conserved Domains (2) summary
      pfam05920
      Location:146185
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. XR_003949337.2 RNA Sequence

    2. XR_001779899.3 RNA Sequence

    3. XR_001779900.3 RNA Sequence