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    Tob2 transducer of ERBB2, 2 [ Mus musculus (house mouse) ]

    Gene ID: 57259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tob2provided by MGI
    Official Full Name
    transducer of ERBB2, 2provided by MGI
    Primary source
    MGI:MGI:1888525
    See related
    Ensembl:ENSMUSG00000048546 AllianceGenome:MGI:1888525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1663; 2900090N22Rik; 4930545K18Rik
    Summary
    Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.9), thymus adult (RPKM 22.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tob2 in Genome Data Viewer
    Location:
    15 E1; 15 38.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81732471..81744742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81848270..81858326, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene thyrotroph embryonic factor Neighboring gene STARR-positive B cell enhancer ABC_E8940 Neighboring gene STARR-positive B cell enhancer ABC_E8599 Neighboring gene predicted gene 8444 Neighboring gene STARR-positive B cell enhancer ABC_E7399 Neighboring gene STARR-positive B cell enhancer ABC_E481 Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_39272 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear vitamin D receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Tob2
    Names
    transducer of erbB-2 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020507.3NP_065253.1  protein Tob2

      See identical proteins and their annotated locations for NP_065253.1

      Status: VALIDATED

      Source sequence(s)
      AK049766, AK143542, AV220845, CK618657, DV644744
      Consensus CDS
      CCDS27673.1
      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Related
      ENSMUSP00000061390.8, ENSMUST00000050467.9
      Conserved Domains (1) summary
      cl15439
      Location:1106
      BTG; BTG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81732471..81744742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159530.1XP_036015423.1  protein Tob2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Conserved Domains (1) summary
      cl15439
      Location:1106
      BTG; BTG family
    2. XM_036159531.1XP_036015424.1  protein Tob2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Conserved Domains (1) summary
      cl15439
      Location:1106
      BTG; BTG family