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    Podxl podocalyxin-like [ Mus musculus (house mouse) ]

    Gene ID: 27205, updated on 9-Dec-2024

    Summary

    Official Symbol
    Podxlprovided by MGI
    Official Full Name
    podocalyxin-likeprovided by MGI
    Primary source
    MGI:MGI:1351317
    See related
    Ensembl:ENSMUSG00000025608 AllianceGenome:MGI:1351317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC; Ly102; Pclp1; PCLP-1; Podxl1
    Summary
    Involved in several processes, including negative regulation of cell-cell adhesion; regulation of microvillus assembly; and regulation of synapse assembly. Acts upstream of or within leukocyte migration. Located in apical plasma membrane and microvillus membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including genitourinary system; integumental system; intraembryonic coelom; nervous system; and sensory organ. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 100.7), kidney adult (RPKM 59.6) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Podxl in Genome Data Viewer
    Location:
    6 A3.3; 6 12.57 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (31496428..31540872, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (31519493..31563937, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210408F21 gene Neighboring gene predicted gene, 38782 Neighboring gene STARR-seq mESC enhancer starr_15487 Neighboring gene muskelin 1, intracellular mediator containing kelch motifs, opposite strand Neighboring gene muskelin 1, intracellular mediator containing kelch motifs Neighboring gene STARR-seq mESC enhancer starr_15489 Neighboring gene STARR-seq mESC enhancer starr_15490 Neighboring gene STARR-positive B cell enhancer mm9_chr6:31546055-31546356 Neighboring gene predicted gene 6117 Neighboring gene predicted gene, 31486

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial tube formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of microvillus assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microvillus membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in slit diaphragm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in slit diaphragm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    podocalyxin
    Names
    podocalyxin-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013723.3NP_038751.2  podocalyxin precursor

      See identical proteins and their annotated locations for NP_038751.2

      Status: VALIDATED

      Source sequence(s)
      AF290209, BY137094
      Consensus CDS
      CCDS19983.1
      UniProtKB/Swiss-Prot
      Q9ESZ1, Q9R0M4
      UniProtKB/TrEMBL
      Q791G4, Q8VIQ4
      Related
      ENSMUSP00000026698.8, ENSMUST00000026698.8
      Conserved Domains (2) summary
      pfam05109
      Location:27295
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam06365
      Location:301502
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      31496428..31540872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)