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    Fgf4 fibroblast growth factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 14175, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fgf4provided by MGI
    Official Full Name
    fibroblast growth factor 4provided by MGI
    Primary source
    MGI:MGI:95518
    See related
    Ensembl:ENSMUSG00000050917 AllianceGenome:MGI:95518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KS3; hst; Fgfk; Hst1; kFGF; Fgf-4; Fgf7a; hst-1; HBGF-4; Hstf-1
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of macromolecule metabolic process; and skeletal system morphogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including branchial pouch; cerebellum; embryo mesenchyme; surface ectoderm; and tooth. Orthologous to human FGF4 (fibroblast growth factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Fgf4 in Genome Data Viewer
    Location:
    7 F5; 7 88.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144415123..144418982)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144861386..144865245)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene Fgf3 upstream enhancer Neighboring gene Fgf3 proximal promoter region Neighboring gene fibroblast growth factor 3 Neighboring gene STARR-seq mESC enhancer starr_20549 Neighboring gene Fgf4 promoter region Neighboring gene Fgf4 3' enhancer Neighboring gene Fgf15 upstream enhancer Neighboring gene Fgf15 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_20554 Neighboring gene predicted gene, 26793 Neighboring gene fibroblast growth factor 15 Neighboring gene predicted gene, 39119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129266, MGC129267

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cartilage condensation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cranial suture morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 4
    Names
    K-fibroblast growth factor
    fibroblast growth factor 7a
    heparin-binding growth factor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010202.6NP_034332.2  fibroblast growth factor 4 precursor

      See identical proteins and their annotated locations for NP_034332.2

      Status: VALIDATED

      Source sequence(s)
      AC161763, AK082814, BB398533
      Consensus CDS
      CCDS22052.1
      UniProtKB/Swiss-Prot
      P11403, P15657, Q542N0
      UniProtKB/TrEMBL
      A0A7U3JW80
      Related
      ENSMUSP00000056752.5, ENSMUST00000060336.5
      Conserved Domains (1) summary
      pfam00167
      Location:83199
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144415123..144418982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)