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    Rgs7 regulator of G protein signaling 7 [ Mus musculus (house mouse) ]

    Gene ID: 24012, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rgs7provided by MGI
    Official Full Name
    regulator of G protein signaling 7provided by MGI
    Primary source
    MGI:MGI:1346089
    See related
    Ensembl:ENSMUSG00000026527 AllianceGenome:MGI:1346089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables GTPase activator activity. Involved in G protein-coupled receptor signaling pathway and regulation of postsynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in dendrite terminus; nucleus; and plasma membrane. Is active in several cellular components, including dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in bone; foot mesenchyme; nervous system; pelvic girdle skeleton; and sensory organ. Orthologous to human RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 16.1), frontal lobe adult (RPKM 12.5) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rgs7 in Genome Data Viewer
    Location:
    1 H3; 1 81.11 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (174886642..175320287, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175059076..175492862, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene formin 2 Neighboring gene predicted gene, 51689 Neighboring gene STARR-seq mESC enhancer starr_03095 Neighboring gene gremlin 2, DAN family BMP antagonist Neighboring gene STARR-seq mESC enhancer starr_03096 Neighboring gene STARR-seq mESC enhancer starr_03097 Neighboring gene STARR-seq mESC enhancer starr_03098 Neighboring gene STARR-seq mESC enhancer starr_03100 Neighboring gene predicted gene, 53483 Neighboring gene STARR-seq mESC enhancer starr_03101 Neighboring gene STARR-positive B cell enhancer ABC_E5859 Neighboring gene STARR-seq mESC enhancer starr_03102 Neighboring gene STARR-positive B cell enhancer ABC_E502 Neighboring gene predicted gene, 36307 Neighboring gene fumarate hydratase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 7
    Names
    Regulator of G-protein signaling 7 (RGS7)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199003.1NP_001185932.1  regulator of G-protein signaling 7 isoform 2

      See identical proteins and their annotated locations for NP_001185932.1

      Status: VALIDATED

      Source sequence(s)
      AI844954, BC051133, CJ060456
      Consensus CDS
      CCDS78755.1
      UniProtKB/TrEMBL
      Q80XD3
      Related
      ENSMUSP00000142180.2, ENSMUST00000194555.6
      Conserved Domains (3) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. NM_001347195.1NP_001334124.1  regulator of G-protein signaling 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102499, AC113050, AC117693, AC117734, AC159973
      Consensus CDS
      CCDS83644.1
      UniProtKB/TrEMBL
      A0A0A6YW36
      Related
      ENSMUSP00000141380.2, ENSMUST00000195324.6
      Conserved Domains (3) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    3. NM_001357129.1NP_001344058.1  regulator of G-protein signaling 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102499, AC113050, AC117693, AC117734, AC159973
      Conserved Domains (3) summary
      smart00224
      Location:203263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2976
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    4. NM_011880.3NP_036010.2  regulator of G-protein signaling 7 isoform 1

      See identical proteins and their annotated locations for NP_036010.2

      Status: VALIDATED

      Source sequence(s)
      AI844954, BC051133, CJ060511
      Consensus CDS
      CCDS15546.1
      UniProtKB/Swiss-Prot
      E9QLB9, O54829
      Related
      ENSMUSP00000142278.2, ENSMUST00000192227.6
      Conserved Domains (3) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      174886642..175320287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496828.5XP_006496891.1  regulator of G-protein signaling 7 isoform X1

      See identical proteins and their annotated locations for XP_006496891.1

      Conserved Domains (4) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    2. XM_017320465.3XP_017175954.1  regulator of G-protein signaling 7 isoform X8

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    3. XM_006496830.5XP_006496893.1  regulator of G-protein signaling 7 isoform X3

      Conserved Domains (4) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    4. XM_011238808.4XP_011237110.1  regulator of G-protein signaling 7 isoform X2

      Conserved Domains (4) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    5. XM_036164663.1XP_036020556.1  regulator of G-protein signaling 7 isoform X6

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    6. XM_017320468.3XP_017175957.1  regulator of G-protein signaling 7 isoform X12

      Conserved Domains (4) summary
      smart00224
      Location:203263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2976
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    7. XM_030253948.2XP_030109808.1  regulator of G-protein signaling 7 isoform X5

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    8. XM_011238809.4XP_011237111.1  regulator of G-protein signaling 7 isoform X10

      Conserved Domains (4) summary
      smart00224
      Location:203263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2976
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    9. XM_036164664.1XP_036020557.1  regulator of G-protein signaling 7 isoform X10

      Conserved Domains (4) summary
      smart00224
      Location:203263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2976
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    10. XM_030253949.2XP_030109809.1  regulator of G-protein signaling 7 isoform X7

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    11. XM_006496831.5XP_006496894.1  regulator of G-protein signaling 7 isoform X4

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    12. XM_006496834.5XP_006496897.1  regulator of G-protein signaling 7 isoform X9

      Conserved Domains (4) summary
      smart00224
      Location:203263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2976
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    13. XM_036164662.1XP_036020555.1  regulator of G-protein signaling 7 isoform X4

      Conserved Domains (4) summary
      smart00224
      Location:239299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:2999
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    14. XM_006496829.5XP_006496892.1  regulator of G-protein signaling 7 isoform X1

      See identical proteins and their annotated locations for XP_006496892.1

      Conserved Domains (4) summary
      smart00224
      Location:256316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
    15. XM_036164665.1XP_036020558.1  regulator of G-protein signaling 7 isoform X11

      Conserved Domains (4) summary
      smart00224
      Location:181241
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:251371
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:241
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:38139
      RGS_DHEX; Regulator of G-protein signalling DHEX domain