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    Rangap1 RAN GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19387, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rangap1provided by MGI
    Official Full Name
    RAN GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:103071
    See related
    Ensembl:ENSMUSG00000022391 AllianceGenome:MGI:103071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fug1; mKIAA1835
    Summary
    Predicted to enable GTPase activator activity; RNA binding activity; and enzyme binding activity. Involved in nuclear export. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; liver; lung; and primitive streak. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 67.3), CNS E11.5 (RPKM 30.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rangap1 in Genome Data Viewer
    Location:
    15 E1; 15 38.21 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81588449..81614120, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81704248..81730798, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene chondroadherin-like Neighboring gene STARR-seq mESC enhancer starr_39263 Neighboring gene STARR-positive B cell enhancer ABC_E1915 Neighboring gene zinc finger CCCH type containing 7B Neighboring gene STARR-seq mESC enhancer starr_39269 Neighboring gene predicted gene, 17597

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vasopressin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear export EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic periphery of the nuclear pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic periphery of the nuclear pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore cytoplasmic filaments IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore cytoplasmic filaments ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ran GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146174.1NP_001139646.1  ran GTPase-activating protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AK159525, BY287991, BY438103
      Consensus CDS
      CCDS27670.1
      UniProtKB/Swiss-Prot
      P46061, Q60801, Q6NZB5
      UniProtKB/TrEMBL
      Q91YS2
      Related
      ENSMUSP00000057771.6, ENSMUST00000052374.13
      Conserved Domains (3) summary
      cd00116
      Location:21358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5181
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:408587
      RanGAP1_C; RanGAP1 C-terminal domain
    2. NM_001358622.1NP_001345551.1  ran GTPase-activating protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (2).
      Source sequence(s)
      AC102262, AC158970
      UniProtKB/TrEMBL
      Q91YS2
      Conserved Domains (3) summary
      cd00116
      Location:69406
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:99129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:456635
      RanGAP1_C; RanGAP1 C-terminal domain
    3. NM_011241.4NP_035371.4  ran GTPase-activating protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AK146670, AK159525, BY287991, BY438103
      Consensus CDS
      CCDS27670.1
      UniProtKB/Swiss-Prot
      P46061, Q60801, Q6NZB5
      UniProtKB/TrEMBL
      Q91YS2
      Related
      ENSMUSP00000126849.2, ENSMUST00000170134.9
      Conserved Domains (3) summary
      cd00116
      Location:21358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5181
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:408587
      RanGAP1_C; RanGAP1 C-terminal domain

    RNA

    1. NR_152441.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC102262, AC158970

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81588449..81614120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_383994.2 RNA Sequence