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    Hrnr hornerin [ Mus musculus (house mouse) ]

    Gene ID: 68723, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hrnrprovided by MGI
    Official Full Name
    hornerinprovided by MGI
    Primary source
    MGI:MGI:3046938
    See related
    Ensembl:ENSMUSG00000041991 AllianceGenome:MGI:3046938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S100a18; 1110033K19Rik; A530063N20Rik
    Summary
    Predicted to enable calcium ion binding activity and transition metal ion binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in foregut; limb digit; and skin. Orthologous to human HRNR (hornerin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 16.2), lung adult (RPKM 12.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Hrnr in Genome Data Viewer
    Location:
    3 F2.1; 3 40.39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (93227056..93240879)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (93319749..93333572)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52644 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 1 Neighboring gene filaggrin Neighboring gene repetin Neighboring gene STARR-seq mESC enhancer starr_08320 Neighboring gene mortality factor 4 like 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of skin barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cornified envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in keratohyalin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratohyalin granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133698.2NP_598459.2  hornerin

      Status: VALIDATED

      Source sequence(s)
      AC158361, AK041026, BB373139
      Consensus CDS
      CCDS50979.1
      UniProtKB/TrEMBL
      E9QNP3
      Related
      ENSMUSP00000088369.4, ENSMUST00000090856.10
      Conserved Domains (2) summary
      cd00213
      Location:289
      S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
      pfam13499
      Location:1375
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      93227056..93240879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501986.4XP_006502049.1  hornerin isoform X1

      UniProtKB/TrEMBL
      F8WJ23
      Related
      ENSMUSP00000091288.4, ENSMUST00000093774.4
      Conserved Domains (2) summary
      PHA03307
      Location:723959
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00213
      Location:289
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    2. XM_006501987.3XP_006502050.1  hornerin isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:723959
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00213
      Location:289
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    3. XM_030252782.1XP_030108642.1  hornerin isoform X4

      Conserved Domains (2) summary
      PHA03307
      Location:15901826
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00213
      Location:289
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    4. XM_030252781.1XP_030108641.1  hornerin isoform X3

      Conserved Domains (2) summary
      PHA03307
      Location:546782
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00213
      Location:289
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...