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    H2bc21 H2B clustered histone 21 [ Mus musculus (house mouse) ]

    Gene ID: 319190, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2bc21provided by MGI
    Official Full Name
    H2B clustered histone 21provided by MGI
    Primary source
    MGI:MGI:2448415
    See related
    Ensembl:ENSMUSG00000068854 AllianceGenome:MGI:2448415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2b-613; Hist2h2be
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of a putative stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
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    Genomic context

    See H2bc21 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96128435..96131057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96221072..96223738)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3450 Neighboring gene STARR-positive B cell enhancer ABC_E1023 Neighboring gene H2A clustered histone 21 Neighboring gene H2A clustered histone 20 Neighboring gene H3 clustered histone 15 Neighboring gene H2A clustered histone 19

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CENP-A containing nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H2B type 2-E
    Names
    histone 2, H2be
    histone cluster 2, H2be

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178214.5NP_835586.2  histone H2B type 2-E

      See identical proteins and their annotated locations for NP_835586.2

      Status: VALIDATED

      Source sequence(s)
      AC125099
      Consensus CDS
      CCDS17635.1
      UniProtKB/Swiss-Prot
      Q64524
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000088287.7, ENSMUST00000090781.8
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96128435..96131057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)