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    Cdc25c cell division cycle 25C [ Mus musculus (house mouse) ]

    Gene ID: 12532, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc25cprovided by MGI
    Official Full Name
    cell division cycle 25Cprovided by MGI
    Primary source
    MGI:MGI:88350
    See related
    Ensembl:ENSMUSG00000044201 AllianceGenome:MGI:88350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc25
    Summary
    This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in CNS E11.5 (RPKM 9.4), liver E14 (RPKM 5.6) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdc25c in Genome Data Viewer
    Location:
    18 B1; 18 18.71 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34866046..34884644, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34732993..34751564, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CDC23 cell division cycle 23 Neighboring gene STARR-seq mESC enhancer starr_44211 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376 Neighboring gene ribosomal protein L29, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E1205 Neighboring gene RIKEN cDNA 2010110K18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7575 Neighboring gene microRNA 12191 Neighboring gene family with sequence similarity 53, member C Neighboring gene predicted gene 3561

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    M-phase inducer phosphatase 3
    Names
    cell cycle phosphatase CDC25C
    cell division cycle control protein 25C
    dual specificity phosphatase Cdc25C
    NP_033990.2
    XP_006525614.1
    XP_011245121.1
    XP_036016849.1
    XP_036016850.1
    XP_036016851.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009860.3NP_033990.2  M-phase inducer phosphatase 3

      See identical proteins and their annotated locations for NP_033990.2

      Status: REVIEWED

      Source sequence(s)
      AC145591, AK141737
      Consensus CDS
      CCDS37759.1
      UniProtKB/Swiss-Prot
      P48967, Q99KG6
      UniProtKB/TrEMBL
      Q3THG4, Q3UR74
      Related
      ENSMUSP00000055427.8, ENSMUST00000060710.9
      Conserved Domains (1) summary
      cd01530
      Location:275394
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34866046..34884644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160957.1XP_036016850.1  M-phase inducer phosphatase 3 isoform X3

      Conserved Domains (1) summary
      cd01530
      Location:89208
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    2. XM_006525551.4XP_006525614.1  M-phase inducer phosphatase 3 isoform X2

      UniProtKB/TrEMBL
      Q3THG4
      Conserved Domains (1) summary
      cd01530
      Location:200319
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    3. XM_036160956.1XP_036016849.1  M-phase inducer phosphatase 3 isoform X1

      UniProtKB/Swiss-Prot
      P48967, Q99KG6
      UniProtKB/TrEMBL
      Q3THG4, Q3UR74
      Conserved Domains (1) summary
      cd01530
      Location:275394
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    4. XM_011246819.2XP_011245121.1  M-phase inducer phosphatase 3 isoform X3

      Conserved Domains (1) summary
      cd01530
      Location:89208
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    5. XM_036160958.1XP_036016851.1  M-phase inducer phosphatase 3 isoform X3

      Conserved Domains (1) summary
      cd01530
      Location:89208
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...