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    Slc25a39 solute carrier family 25, member 39 [ Mus musculus (house mouse) ]

    Gene ID: 68066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a39provided by MGI
    Official Full Name
    solute carrier family 25, member 39provided by MGI
    Primary source
    MGI:MGI:1196386
    See related
    Ensembl:ENSMUSG00000018677 AllianceGenome:MGI:1196386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D11Ertd333e; 3010027G13Rik
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and glutathione transmembrane transporter activity. Predicted to be involved in cellular response to iron ion and glutathione import into mitochondrion. Located in mitochondrion. Is expressed in several structures, including alimentary system; extraembryonic component; liver; nervous system; and skeleton. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 285.8), kidney adult (RPKM 222.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a39 in Genome Data Viewer
    Location:
    11 D; 11 66.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102293795..102299501, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102402969..102408675, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene STARR-positive B cell enhancer ABC_E11495 Neighboring gene RUN domain containing 3A Neighboring gene STARR-positive B cell enhancer ABC_E5282 Neighboring gene microRNA 6930 Neighboring gene STARR-seq mESC enhancer starr_30808 Neighboring gene STARR-positive B cell enhancers ABC_E9375 and ABC_E8457 Neighboring gene granulin Neighboring gene family with sequence similarity 171, member A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Wang Y, et al. Nature, 2021 Nov. PMID 34707288, Free PMC Article
    2. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
      Title: SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
    2. Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis.
      Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144572, MGC144573

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to iron ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to iron ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026542.3 → NP_080818.1  mitochondrial glutathione transporter SLC25A39

      See identical proteins and their annotated locations for NP_080818.1

      Status: VALIDATED

      Source sequence(s)
      AK161289, BU758028, BY291748
      Consensus CDS
      CCDS25498.1
      UniProtKB/Swiss-Prot
      Q3TTM8, Q9D8K8
      UniProtKB/TrEMBL
      A2A697, Q14BQ5
      Related
      ENSMUSP00000018821.3, ENSMUST00000018821.9
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102293795..102299501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534035.1 → XP_006534098.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      See identical proteins and their annotated locations for XP_006534098.1

      UniProtKB/Swiss-Prot
      Q3TTM8, Q9D8K8
      UniProtKB/TrEMBL
      A2A697, Q14BQ5
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    2. XM_006534036.4 → XP_006534099.1  probable mitochondrial glutathione transporter SLC25A39 isoform X2

      UniProtKB/TrEMBL
      A2A697
      Related
      ENSMUSP00000115445.2, ENSMUST00000155104.8
      Conserved Domains (2) summary
      pfam00153
      Location:9 → 152
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    3. XM_006534034.2 → XP_006534097.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      See identical proteins and their annotated locations for XP_006534097.1

      UniProtKB/Swiss-Prot
      Q3TTM8, Q9D8K8
      UniProtKB/TrEMBL
      A2A697, Q14BQ5
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    4. XM_030246255.1 → XP_030102115.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

      UniProtKB/Swiss-Prot
      Q3TTM8, Q9D8K8
      UniProtKB/TrEMBL
      A2A697, Q14BQ5
      Conserved Domains (2) summary
      pfam00153
      Location:254 → 350
      Mito_carr; Mitochondrial carrier protein
      pfam18398
      Location:71 → 94
      CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

    5. XM_030246256.1 → XP_030102116.1  probable mitochondrial glutathione transporter SLC25A39 isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:153 → 249
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8K8.1 GenPept UniProtKB/Swiss-Prot:Q9D8K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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