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    Odad3 outer dynein arm docking complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 77609, updated on 9-Dec-2024

    Summary

    Official Symbol
    Odad3provided by MGI
    Official Full Name
    outer dynein arm docking complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1924859
    See related
    Ensembl:ENSMUSG00000039632 AllianceGenome:MGI:1924859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc151; b2b1885Clo; C330001K17Rik
    Summary
    Involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Acts upstream of or within several processes, including determination of heart left/right asymmetry; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Located in centriole and ciliary basal body. Is expressed in node; testis; and trachea. Used to study Kartagener syndrome and primary ciliary dyskinesia 30. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 15.6), CNS E18 (RPKM 2.1) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Odad3 in Genome Data Viewer
    Location:
    9 A3; 9 8.01 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21901167..21914268, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21989871..22002972, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene erythropoietin receptor Neighboring gene ral guanine nucleotide dissociation stimulator-like 3 Neighboring gene predicted gene, 36414 Neighboring gene protein kinase C substrate 80K-H Neighboring gene ELAV like RNA binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebrospinal fluid circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary rootlet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in ciliary tip IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer dynein arm docking complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in sperm flagellum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    outer dynein arm-docking complex subunit 3
    Names
    coiled-coil domain containing 151
    coiled-coil domain-containing protein 151

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163787.1NP_001157259.1  outer dynein arm-docking complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_001157259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163623, AK021166, BC057069
      Consensus CDS
      CCDS52740.1
      UniProtKB/TrEMBL
      A0A0R4J1K3
      Related
      ENSMUSP00000110993.3, ENSMUST00000115336.10
      Conserved Domains (1) summary
      COG1196
      Location:64437
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. NM_029939.3NP_084215.2  outer dynein arm-docking complex subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_084215.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC163623, AK031175, BC057069
      Consensus CDS
      CCDS22917.1
      UniProtKB/Swiss-Prot
      G3X951, Q6PGE8, Q8BSN3, Q9CWC6
      Related
      ENSMUSP00000041117.6, ENSMUST00000044926.6
      Conserved Domains (1) summary
      COG1196
      Location:64436
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21901167..21914268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242626.1XP_011240928.1  outer dynein arm-docking complex subunit 3 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:79451
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_011242625.1XP_011240927.1  outer dynein arm-docking complex subunit 3 isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:79452
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_006510685.2XP_006510748.1  outer dynein arm-docking complex subunit 3 isoform X3

      See identical proteins and their annotated locations for XP_006510748.1

      UniProtKB/TrEMBL
      A0A0R4J1K3
      Conserved Domains (1) summary
      COG1196
      Location:64437
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. XM_006510687.3XP_006510750.1  outer dynein arm-docking complex subunit 3 isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:3257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type