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    Nrn1l neuritin 1-like [ Mus musculus (house mouse) ]

    Gene ID: 234700, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrn1lprovided by MGI
    Official Full Name
    neuritin 1-likeprovided by MGI
    Primary source
    MGI:MGI:2443642
    See related
    Ensembl:ENSMUSG00000044287 AllianceGenome:MGI:2443642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpg15-2; G630049C14Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within neuron projection extension. Located in axon; extracellular space; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; retina; and spleen. Orthologous to human NRN1L (neuritin 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.1), adrenal adult (RPKM 2.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nrn1l in Genome Data Viewer
    Location:
    8 D3; 8 53.06 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106620199..106621655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105893567..105895023)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene nuclear transport factor 2 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene STARR-positive B cell enhancer ABC_E3800 Neighboring gene protein serine kinase H1 Neighboring gene STARR-positive B cell enhancer ABC_E6679 Neighboring gene chymotrypsin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in neuron projection extension IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron projection extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuritin-like protein
    Names
    MRCC2446-like protein
    candidate plasticity gene 15-2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301174.1NP_001288103.1  neuritin-like protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001288103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK080711, BC100315, CK030777
      Consensus CDS
      CCDS80924.1
      UniProtKB/Swiss-Prot
      Q8C4W3
      Related
      ENSMUSP00000113445.2, ENSMUST00000118920.2
      Conserved Domains (1) summary
      pfam15056
      Location:38113
      NRN1; Neuritin protein family
    2. NM_175024.4NP_778189.1  neuritin-like protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_778189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC100315, CK030777
      Consensus CDS
      CCDS22618.1
      UniProtKB/Swiss-Prot
      Q8BN06, Q8C4W3
      Related
      ENSMUSP00000056940.6, ENSMUST00000060167.6
      Conserved Domains (1) summary
      pfam15056
      Location:39114
      NRN1; Neuritin protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106620199..106621655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)