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    Cxcl9 C-X-C motif chemokine ligand 9 [ Mus musculus (house mouse) ]

    Gene ID: 17329, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cxcl9provided by MGI
    Official Full Name
    C-X-C motif chemokine ligand 9provided by MGI
    Primary source
    MGI:MGI:1352449
    See related
    Ensembl:ENSMUSG00000029417 AllianceGenome:MGI:1352449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMK; Mig; MuMIG; Scyb9; crg-10
    Summary
    Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; limb; retina; testis; and thymus. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 7.5), mammary gland adult (RPKM 6.2) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cxcl9 in Genome Data Viewer
    Location:
    5 E2; 5 46.51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92469190..92475938, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92321331..92328079, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene N-acylethanolamine acid amidase Neighboring gene STARR-positive B cell enhancer ABC_E10329 Neighboring gene STARR-positive B cell enhancer ABC_E2750 Neighboring gene STARR-seq mESC enhancer starr_13638 Neighboring gene SDA1 domain containing 1 Neighboring gene predicted gene, 23031 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92777801-92778102 Neighboring gene ADP-ribosyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_13640 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene chemokine (C-X-C motif) ligand 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CXCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables CXCR3 chemokine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-X-C motif chemokine 9
    Names
    M119
    chemokine (C-X-C motif) ligand 9
    gamma interferon-induced monokine
    monokine induced by gamma interferon
    monokine induced by interferon-gamma
    protein m119
    small inducible cytokine B subfamily (Cys-X-Cys), member 9
    small-inducible cytokine B9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008599.4NP_032625.2  C-X-C motif chemokine 9 precursor

      See identical proteins and their annotated locations for NP_032625.2

      Status: VALIDATED

      Source sequence(s)
      AC122365, AK042017
      Consensus CDS
      CCDS39152.1
      UniProtKB/Swiss-Prot
      P18340, Q8C9J0, Q99J60
      UniProtKB/TrEMBL
      Q8C9B8
      Related
      ENSMUSP00000108716.4, ENSMUST00000113093.5
      Conserved Domains (1) summary
      cd00273
      Location:2989
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92469190..92475938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)