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    A4gnt alpha-1,4-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 333424, updated on 9-Dec-2024

    Summary

    Official Symbol
    A4gntprovided by MGI
    Official Full Name
    alpha-1,4-N-acetylglucosaminyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2143261
    See related
    Ensembl:ENSMUSG00000037953 AllianceGenome:MGI:2143261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm798; Alpha4gnt
    Summary
    This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]
    Expression
    Biased expression in stomach adult (RPKM 13.0), duodenum adult (RPKM 7.6) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See A4gnt in Genome Data Viewer
    Location:
    9 E3.3; 9 51.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99473233..99504420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99591179..99622367)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene debranching RNA lariats 1 Neighboring gene DAZ interacting protein 1-like Neighboring gene claudin 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General protein information

    Preferred Names
    alpha-1,4-N-acetylglucosaminyltransferase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077424.2NP_001070892.1  alpha-1,4-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001070892.1

      Status: REVIEWED

      Source sequence(s)
      AC157949, AK136425
      Consensus CDS
      CCDS40740.1
      UniProtKB/Swiss-Prot
      Q14BT6
      Related
      ENSMUSP00000045629.8, ENSMUST00000042553.8
      Conserved Domains (2) summary
      pfam04488
      Location:65183
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:202324
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      99473233..99504420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511246.5XP_006511309.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006511309.1

      UniProtKB/Swiss-Prot
      Q14BT6
      Conserved Domains (2) summary
      pfam04488
      Location:65183
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:202324
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    2. XM_006511244.5XP_006511307.3  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

      Conserved Domains (2) summary
      pfam04488
      Location:130248
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:267389
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region