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    CMTM4 CKLF like MARVEL transmembrane domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 146223, updated on 9-Dec-2024

    Summary

    Official Symbol
    CMTM4provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:19175
    See related
    Ensembl:ENSG00000183723 MIM:607887; AllianceGenome:HGNC:19175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLFSF4
    Summary
    This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 48.0), kidney (RPKM 20.0) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CMTM4 in Genome Data Viewer
    Location:
    16q21-q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66598178..66696743, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72359915..72491037, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66648653..66730646, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66642903-66643714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66653785-66654286 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66677635-66677813 Neighboring gene Sharpr-MPRA regulatory region 8452 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66708833-66709036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66710611-66711112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66725551-66726230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726231-66726910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726911-66727590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66729849-66730688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7566 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2 Neighboring gene MPRA-validated peak2616 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66785153-66785868 Neighboring gene DYNC1LI2 divergent transcript Neighboring gene telomere repeat binding bouquet formation protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Names
    chemokine-like factor super family 4
    chemokine-like factor superfamily member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178818.3NP_848933.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_848933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC018557, AF521889
      Consensus CDS
      CCDS10817.1
      UniProtKB/Swiss-Prot
      Q52M40, Q8IZR4, Q8IZR5, Q8IZV1
      Related
      ENSP00000333833.4, ENST00000330687.8
      Conserved Domains (1) summary
      pfam01284
      Location:49170
      MARVEL; Membrane-associating domain
    2. NM_181521.3NP_852662.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_852662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an additional segment in the 3' coding region that leads to an upstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC018557, AF479814, AW207043
      Consensus CDS
      CCDS42170.1
      UniProtKB/Swiss-Prot
      Q8IZR5
      Related
      ENSP00000377666.2, ENST00000394106.7
      Conserved Domains (1) summary
      pfam01284
      Location:49170
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66598178..66696743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022954.2XP_016878443.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

    2. XM_011522882.2XP_011521184.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_011521184.1

      UniProtKB/Swiss-Prot
      Q8IZR5
      Related
      ENSP00000456380.1, ENST00000563952.1
      Conserved Domains (1) summary
      pfam01284
      Location:34141
      MARVEL; Membrane-associating domain

    RNA

    1. XR_933209.3 RNA Sequence

    2. XR_933210.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72359915..72491037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379651.1XP_054235626.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X3

    2. XM_054379652.1XP_054235627.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X4

    3. XM_054379653.1XP_054235628.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X5

    4. XM_054379654.1XP_054235629.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X6

    5. XM_054379655.1XP_054235630.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

    6. XM_054379656.1XP_054235631.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

    RNA

    1. XR_008489057.1 RNA Sequence

    2. XR_008489058.1 RNA Sequence