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    BCR BCR activator of RhoGEF and GTPase [ Homo sapiens (human) ]

    Gene ID: 613, updated on 27-Nov-2024

    Summary

    Official Symbol
    BCRprovided by HGNC
    Official Full Name
    BCR activator of RhoGEF and GTPaseprovided by HGNC
    Primary source
    HGNC:HGNC:1014
    See related
    Ensembl:ENSG00000186716 MIM:151410; AllianceGenome:HGNC:1014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALL; CML; PHL; BCR1; D22S11; D22S662
    Summary
    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
    Expression
    Ubiquitous expression in testis (RPKM 14.9), brain (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BCR in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23180509..23318037)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (23603367..23740899)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23522696..23660224)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene radial spoke head 14 homolog Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:23491660-23492160 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:23492161-23492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23498179-23498784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23508841-23509342 Neighboring gene RAB36, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 7478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13533 Neighboring gene RAB36-BCR intergenic enhancer-blocking element 22-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23521616-23522426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23526972-23527478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23534525-23535026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23535027-23535526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23536731-23537231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23541159-23542100 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23543528-23543704 Neighboring gene BCR pseudogene 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23559755-23560544 Neighboring gene BCR-ABL minor-breakpoint cluster region Neighboring gene Sharpr-MPRA regulatory region 5876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18750 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23564024-23564225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:23571548-23572282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18751 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23584482-23585232 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23585233-23585984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23591289-23591814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23599428-23600084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23611303-23611973 Neighboring gene BCR-ABL p195 breakpoint cluster region Neighboring gene RNA, 7SL, cytoplasmic 263, pseudogene Neighboring gene BCR-ABL p200 breakpoint cluster region Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23621943-23622250 Neighboring gene F-box and WD repeat domain containing 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13538 Neighboring gene uncharacterized LOC107985554 Neighboring gene BCR-ABL major-breakpoint cluster region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18755 Neighboring gene BCR-ABL p225 breakpoint cluster region Neighboring gene BCR-ABL micro-breakpoint cluster region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23656171-23656672 Neighboring gene Sharpr-MPRA regulatory region 15419 Neighboring gene POM121 transmembrane nucleoporin like 11, pseudogene Neighboring gene long intergenic non-protein coding RNA 2556 Neighboring gene ribosomal protein S10 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Acute lymphoid leukemia
    MedGen: C0023449 OMIM: 613065 GeneReviews: Not available
    not available
    Chronic myelogenous leukemia, BCR-ABL1 positive
    MedGen: C0279543 OMIM: 608232 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-10)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-10)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome-wide association study of antibody response to smallpox vaccine.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of breakpoint cluster region (BCR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16453

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular extravasation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of respiratory burst IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    breakpoint cluster region protein
    Names
    BCR, RhoGEF and GTPase activating protein
    BCR/FGFR1 chimera protein
    FGFR1/BCR chimera protein
    breakpoint cluster region
    renal carcinoma antigen NY-REN-26
    NP_004318.3
    NP_067585.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009244.2 RefSeqGene

      Range
      5145..142673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1112

    mRNA and Protein(s)

    1. NM_004327.4NP_004318.3  breakpoint cluster region protein isoform 1

      See identical proteins and their annotated locations for NP_004318.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC066122, BQ422888, U07000, X02596
      Consensus CDS
      CCDS13806.1
      UniProtKB/Swiss-Prot
      P11274, P78501, Q12842, Q4LE80, Q6NZI3
      UniProtKB/TrEMBL
      A0A2X0SFQ7
      Related
      ENSP00000303507.8, ENST00000305877.13
      Conserved Domains (6) summary
      cd08686
      Location:9131033
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:10521252
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13367
      Location:684877
      PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      pfam00621
      Location:502690
      RhoGEF; RhoGEF domain
      pfam07001
      Location:81174
      BAT2_N; BAT2 N-terminus
      pfam09036
      Location:375
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    2. NM_021574.3NP_067585.2  breakpoint cluster region protein isoform 2

      See identical proteins and their annotated locations for NP_067585.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC066122, BQ422888, U07000, Y00661
      Consensus CDS
      CCDS13807.1
      UniProtKB/TrEMBL
      A0A2X0SFQ7
      Related
      ENSP00000352535.3, ENST00000359540.7
      Conserved Domains (6) summary
      cd04387
      Location:10081208
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13367
      Location:684877
      PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      pfam00621
      Location:502690
      RhoGEF; RhoGEF domain
      pfam07001
      Location:81174
      BAT2_N; BAT2 N-terminus
      pfam09036
      Location:375
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
      cl14603
      Location:913989
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23180509..23318037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      23603367..23740899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)