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    DGKA diacylglycerol kinase alpha [ Homo sapiens (human) ]

    Gene ID: 1606, updated on 9-Dec-2024

    Summary

    Official Symbol
    DGKAprovided by HGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:2849
    See related
    Ensembl:ENSG00000065357 MIM:125855; AllianceGenome:HGNC:2849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAGK; DAGK1; DGK-alpha
    Summary
    The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
    Expression
    Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DGKA in Genome Data Viewer
    Location:
    12q13.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55927316..55954023)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55894378..55921085)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56321100..56347807)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase pi 1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:56302402-56302550 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene uncharacterized LOC124902941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4539 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56320788-56321368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56321369-56321949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56333724-56334224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56334225-56334725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56350689-56351190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56354315-56354815 Neighboring gene premelanosome protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6464 Neighboring gene cyclin dependent kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12821, MGC42356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent diacylglycerol kinase activity TAS
    Traceable Author Statement
    more info
     
    enables alkylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase alpha
    Names
    80 kDa diacylglycerol kinase
    DAG kinase alpha
    diacylglycerol kinase, alpha 80kDa
    diglyceride kinase alpha
    NP_001336.2
    NP_001337962.1
    NP_001337963.1
    NP_001337964.1
    NP_001337965.1
    NP_001337966.1
    NP_001337967.1
    NP_001337968.1
    NP_001337969.1
    NP_001400525.1
    NP_001400526.1
    NP_001400527.1
    NP_001400528.1
    NP_001400529.1
    NP_001400530.1
    NP_001400531.1
    NP_001400532.1
    NP_001400533.1
    NP_958852.1
    NP_958853.1
    NP_963848.1
    XP_011536297.1
    XP_016874389.1
    XP_016874390.1
    XP_016874391.1
    XP_016874396.1
    XP_016874397.1
    XP_047284390.1
    XP_047284391.1
    XP_047284392.1
    XP_047284393.1
    XP_054227256.1
    XP_054227257.1
    XP_054227258.1
    XP_054227259.1
    XP_054227260.1
    XP_054227261.1
    XP_054227262.1
    XP_054227263.1
    XP_054227264.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001345.5NP_001336.2  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_001336.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 2, 4-6, and 15-17, encodes isoform a.
      Source sequence(s)
      BC023523, BC031870, BM836118, BQ943057
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Related
      ENSP00000328405.5, ENST00000331886.10
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    2. NM_001351033.2NP_001337962.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4, 6, and 15-17, encodes isoform a.
      Source sequence(s)
      AC025162, BC031870
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Related
      ENSP00000450359.1, ENST00000551156.5
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    3. NM_001351034.2NP_001337963.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1-5 and 15-17, encodes isoform a.
      Source sequence(s)
      AC025162
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    4. NM_001351035.1NP_001337964.1  diacylglycerol kinase alpha isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (b).
      Source sequence(s)
      AC025162
      Conserved Domains (5) summary
      smart00045
      Location:558739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:244292
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:42148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    5. NM_001351036.2NP_001337965.1  diacylglycerol kinase alpha isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform c.
      Source sequence(s)
      AC025162
      UniProtKB/TrEMBL
      G3V4E1
      Conserved Domains (4) summary
      smart00045
      Location:379560
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:65113
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    6. NM_001351037.1NP_001337966.1  diacylglycerol kinase alpha isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform c.
      Source sequence(s)
      AC025162
      UniProtKB/TrEMBL
      G3V4E1
      Conserved Domains (4) summary
      smart00045
      Location:379560
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:65113
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    7. NM_001351038.2NP_001337967.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    8. NM_001351039.2NP_001337968.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    9. NM_001351040.2NP_001337969.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    10. NM_001413596.1NP_001400525.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Source sequence(s)
      AC025162
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    11. NM_001413597.1NP_001400526.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Source sequence(s)
      AC025162
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    12. NM_001413598.1NP_001400527.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Source sequence(s)
      AC025162
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    13. NM_001413599.1NP_001400528.1  diacylglycerol kinase alpha isoform e

      Status: REVIEWED

      Source sequence(s)
      AC025162
    14. NM_001413600.1NP_001400529.1  diacylglycerol kinase alpha isoform e

      Status: REVIEWED

      Source sequence(s)
      AC025162
    15. NM_001413601.1NP_001400530.1  diacylglycerol kinase alpha isoform e

      Status: REVIEWED

      Source sequence(s)
      AC025162
    16. NM_001413602.1NP_001400531.1  diacylglycerol kinase alpha isoform f

      Status: REVIEWED

      Source sequence(s)
      AC025162
    17. NM_001413603.1NP_001400532.1  diacylglycerol kinase alpha isoform f

      Status: REVIEWED

      Source sequence(s)
      AC025162
    18. NM_001413604.1NP_001400533.1  diacylglycerol kinase alpha isoform g

      Status: REVIEWED

      Source sequence(s)
      AC025162
    19. NM_201444.3NP_958852.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_958852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2-6 and 15-17, encodes isoform a.
      Source sequence(s)
      AI815678, BC023523, BC031870, BM910598
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Related
      ENSP00000377703.1, ENST00000394147.5
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    20. NM_201445.2NP_958853.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_958853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 3-6, and 15-17, encodes isoform a.
      Source sequence(s)
      BC023523, BC031870, BF448612
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    21. NM_201554.2NP_963848.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_963848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3, 5, 6, and 15-17, encodes isoform a.
      Source sequence(s)
      BC023523, BC031870, BF448612
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4110
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RNA

    1. NR_147026.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025162
      Related
      ENST00000402956.7
    2. NR_147027.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025162

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      55927316..55954023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018901.3XP_016874390.1  diacylglycerol kinase alpha isoform X2

    2. XM_047428435.1XP_047284391.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    3. XM_017018907.2XP_016874396.1  diacylglycerol kinase alpha isoform X2

    4. XM_047428434.1XP_047284390.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    5. XM_017018902.2XP_016874391.1  diacylglycerol kinase alpha isoform X2

    6. XM_017018900.1XP_016874389.1  diacylglycerol kinase alpha isoform X1

    7. XM_017018908.1XP_016874397.1  diacylglycerol kinase alpha isoform X3

    8. XM_047428436.1XP_047284392.1  diacylglycerol kinase alpha isoform X5

    9. XM_047428437.1XP_047284393.1  diacylglycerol kinase alpha isoform X6

    10. XM_011537995.3XP_011536297.1  diacylglycerol kinase alpha isoform X7

      See identical proteins and their annotated locations for XP_011536297.1

      Related
      ENST00000549079.6
      Conserved Domains (4) summary
      smart00045
      Location:408589
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:266387
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:94142
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:3071
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      55894378..55921085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371283.1XP_054227258.1  diacylglycerol kinase alpha isoform X2

    2. XM_054371284.1XP_054227259.1  diacylglycerol kinase alpha isoform X2

    3. XM_054371286.1XP_054227261.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/Swiss-Prot
      O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
    4. XM_054371282.1XP_054227257.1  diacylglycerol kinase alpha isoform X2

    5. XM_054371281.1XP_054227256.1  diacylglycerol kinase alpha isoform X1

    6. XM_054371285.1XP_054227260.1  diacylglycerol kinase alpha isoform X3

    7. XM_054371287.1XP_054227262.1  diacylglycerol kinase alpha isoform X5

    8. XM_054371288.1XP_054227263.1  diacylglycerol kinase alpha isoform X6

    9. XM_054371289.1XP_054227264.1  diacylglycerol kinase alpha isoform X7