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    DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 [ Homo sapiens (human) ]

    Gene ID: 1783, updated on 9-Dec-2024

    Summary

    Official Symbol
    DYNC1LI2provided by HGNC
    Official Full Name
    dynein cytoplasmic 1 light intermediate chain 2provided by HGNC
    Primary source
    HGNC:HGNC:2966
    See related
    Ensembl:ENSG00000135720 MIM:611406; AllianceGenome:HGNC:2966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIC2; DNCLI2
    Summary
    Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 55.8), thyroid (RPKM 40.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DYNC1LI2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66720893..66751609, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72515191..72545899, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66754796..66785512, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66642903-66643714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66653785-66654286 Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66677635-66677813 Neighboring gene Sharpr-MPRA regulatory region 8452 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66708833-66709036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66710611-66711112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66725551-66726230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726231-66726910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726911-66727590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66729849-66730688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7566 Neighboring gene MPRA-validated peak2616 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66785153-66785868 Neighboring gene DYNC1LI2 divergent transcript Neighboring gene MPRA-validated peak2617 silencer Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66864603-66865103 Neighboring gene NEDD8 activating enzyme E1 subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of dynein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytoplasmic dynein 1 light intermediate chain 2
    Names
    LIC-2
    LIC53/55
    dynein light intermediate chain 2, cytosolic
    dynein, cytoplasmic, light intermediate polypeptide 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286157.2NP_001273086.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 2

      See identical proteins and their annotated locations for NP_001273086.1

      Status: VALIDATED

      Source sequence(s)
      AC018557, AK303031, AL708642, BC022934
      Consensus CDS
      CCDS67049.1
      UniProtKB/Swiss-Prot
      O43237
      Related
      ENSP00000394289.2, ENST00000443351.6
      Conserved Domains (1) summary
      pfam05783
      Location:30411
      DLIC; Dynein light intermediate chain (DLIC)
    2. NM_001323955.2NP_001310884.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC018557, AC044802, BC022934, BU616879, BX648863, DC417195, EB387189
      UniProtKB/TrEMBL
      Q63HJ8
      Conserved Domains (1) summary
      pfam05783
      Location:30449
      DLIC; Dynein light intermediate chain (DLIC)
    3. NM_006141.3NP_006132.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 1

      See identical proteins and their annotated locations for NP_006132.1

      Status: VALIDATED

      Source sequence(s)
      AC018557, AF035812, AL708642, BC022934, BM805417, BX648863
      Consensus CDS
      CCDS10818.1
      UniProtKB/Swiss-Prot
      A8K6V1, B4DZP4, O43237, Q8TAT3
      Related
      ENSP00000258198.2, ENST00000258198.7
      Conserved Domains (1) summary
      pfam05783
      Location:30488
      DLIC; Dynein light intermediate chain (DLIC)

    RNA

    1. NR_136658.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018557, BC010928, BX648863

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66720893..66751609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023008.2XP_016878497.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72515191..72545899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379724.1XP_054235699.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1