MAGEC1 MAGE family member C1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAGEC1provided by HGNC
Official Full Name: MAGE family member C1provided by HGNC
Primary source: HGNC:HGNC:6812
See related: Ensembl:ENSG00000155495 MIM:300223; AllianceGenome:HGNC:6812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT7; CT7.1
Summary: This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward testis (RPKM 5.4) See more
Orthologs: all
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Genomic context

Location:: Xq27.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (141903894..141909374)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (140212676..140218187)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (140991680..140997160)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Association of Melanoma-Associated Antigen-C Gene With Clinicopathological Characteristics and Prognosis in Breast Cancer: A Systematic Review and Meta-Analysis.
Title: The Association of Melanoma-Associated Antigen-C Gene With Clinicopathological Characteristics and Prognosis in Breast Cancer: A Systematic Review and Meta-Analysis.
Results suggest that melanoma antigen, family C, 1 protein (MAGE-C1/CT7) expression is associated with inferior outcome of patients with multiple myeloma (MM) from a Chinese population.
Title: Expression of MAGE-C1/CT7 provides prognostic information in multiple myeloma.
In patients with Colon cancer, the expression of MAGE-C1 gene was related to a favorable prognosis.
Title: [Cancer-testis genes in colon cancer].
MAGE-C1 and MAGE-C2 expressions were positively associated with high tumor grade and reduced recurrence-free survival in breast cancer.
Title: The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance.
MAGE C1 expression was observed consistently in the early stem cells (CD34+) and early pro-B to pre-B cells (CD34+/-/CD19+), as well as the proliferating plasma cells.
Title: The use of MAGE C1 and flow cytometry to determine the malignant cell type in multiple myeloma.
expression of CT7 and CT10 throughout the different subtypes of mucosal melanoma and tumor development.
Title: Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
MAGE-C1 and MAGE-C2 are expressed in myeloma, but the chromosome aberrations do not always correlate with expression
Title: Chromosomal aberrations of cancer-testis antigens in myeloma patients.
MAGEC1/CT7 was expressed in 66% of MM samples.
Title: Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?
Study identified the YKL40 and MAGEC1 genes as temozolomide (TMZ) resistanceassociated biomarkers in the TMZR U87 cell line, which showed an obvious resistance in vivo.
Title: YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line.
Positive results of immunohistostaining were obtained in 16 (35.6%), 7 (15.6%) and 36 (80.0%) samples using MAGE-C1, NY-ESO-1 and Sp17 antibodies, respectively
Title: Sperm protein 17, MAGE-C1 and NY-ESO-1 in hepatocellular carcinoma: expression frequency and their correlation with clinical parameters.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MAGEC3__7360 (e-PCR)
- UniSTS:471487

MAGEC1_1817 (e-PCR)
- UniSTS:277463

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanoma-associated antigen C1

Names: MAGE-C1 antigen; cancer/testis antigen 7.1; cancer/testis antigen family 7, member 1; melanoma antigen family C, 1; melanoma antigen family C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.