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    NUP210 nucleoporin 210 [ Homo sapiens (human) ]

    Gene ID: 23225, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NUP210provided by HGNC
    Official Full Name
    nucleoporin 210provided by HGNC
    Primary source
    HGNC:HGNC:30052
    See related
    Ensembl:ENSG00000132182 MIM:607703; AllianceGenome:HGNC:30052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP210; POM210
    Summary
    The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in lymph node (RPKM 17.2), bone marrow (RPKM 15.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NUP210 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (13316235..13420322, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (13316581..13420679, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13357735..13461822, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19466 Neighboring gene uncharacterized LOC124906214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055383-13055884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055885-13056384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13056642-13057410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13057411-13058178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19470 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13058755-13059554 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13059555-13060352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13060353-13061150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068313-13068814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068815-13069314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13072358-13073358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13073359-13074357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13076449-13076949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13083243-13083838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13088478-13088996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13098528-13099036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13099037-13099544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13121681-13122182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13122183-13122682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14083 Neighboring gene ribosomal protein L39 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13129843-13130342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13144801-13145570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13202841-13203366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13212946-13213470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13213471-13213994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13215820-13216320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13234555-13235161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13235162-13235768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13239281-13239901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13240462-13241008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13250445-13250980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13250981-13251518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261232-13261755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261756-13262278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13262279-13262801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13273335-13273836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279021-13279625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279626-13280229 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13283606-13283809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13295276-13296085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13296086-13296894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298218-13298718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298719-13299219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13301694-13302474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13318107-13318607 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13318634-13318918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13319003-13319504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19485 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13363927-13364126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368867-13369366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368365-13368866 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13372259-13372426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13387355-13388236 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13388237-13389120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13389121-13390003 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13390887-13391769 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13415591-13416092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13430034-13430534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13432338-13432896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13440837-13441368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13441369-13441898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13442941-13443441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14085 Neighboring gene NUP210-HDAC11 intergenic CAGE-defined high expression enhancer Neighboring gene Sharpr-MPRA regulatory region 3172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19491 Neighboring gene HDAC11 antisense RNA 1 Neighboring gene PRR3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. Greber UF, et al. EMBO J, 1990 May. PMID 2184032, Free PMC Article
    2. Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth. Kondo H, et al. Cells, 2022 Jan 18. PMID 35159127, Free PMC Article
    3. Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia. Li M, et al. Hematology, 2022 Dec. PMID 35413221
    4. Polyproline type II conformation in the C-terminal domain of the nuclear pore complex protein gp210. Pilpel Y, et al. Biochemistry, 2003 Apr 1. PMID 12653556
    5. Early Prognostic Utility of Gp210 Antibody-Positive Rate in Primary Biliary Cholangitis: A Meta-Analysis. Huang C, et al. Dis Markers, 2019. PMID 31737133, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia.
      Title: Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia.
    2. Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth.
      Title: Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth.
    3. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
      Title: Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
    4. Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer.
      Title: Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer.
    5. NUP205 and NUP210 mutations are associated with defects in cardiac patterning.
      Title: Bi-Allelic Mutations in NUP205 and NUP210 Are Associated With Abnormal Cardiac Left-Right Patterning.
    6. miR-22-regulated expression of NUP210 could alter Fas expression and, in turn, elicit cell cycle arrest and proliferation.
      Title: NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest.
    7. Primary biliary cholangitis-specific Gp120 antibodies are optimal predictors of primary biliary cholangitis prognosis at the time of diagnosis.
      Title: Early Prognostic Utility of Gp210 Antibody-Positive Rate in Primary Biliary Cholangitis: A Meta-Analysis.
    8. Nucleoporin GP210 is involved in endometriosis. Rs354476 polymorphism affects the regulation of NUP210 gene expression by altering the binding with hsa-miR-125b-5p, a microRNA already known as playing an important role for endometriosis. This provides the rationale for the observed increased risk of endometriosis in carriers of the variant allele.
      Title: Functional polymorphism within NUP210 encoding for nucleoporin GP210 is associated with the risk of endometriosis.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with NUP210 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22389, KIAA0906

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear pore membrane glycoprotein 210
    Names
    nuclear envelope pore membrane protein POM 210
    nuclear pore protein gp210
    nucleoporin 210kDa
    nucleoporin Nup210
    pore membrane protein of 210 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024923.4 → NP_079199.2  nuclear pore membrane glycoprotein 210 precursor

      See identical proteins and their annotated locations for NP_079199.2

      Status: REVIEWED

      Source sequence(s)
      AB020713, AC027124, AK074101, BC067089, BM508095, HY177936
      Consensus CDS
      CCDS33704.1
      UniProtKB/Swiss-Prot
      A6NN56, O94980, Q6NXG6, Q8NBJ1, Q8TEM1, Q9H6C8, Q9UFP3
      Related
      ENSP00000254508.5, ENST00000254508.7
      Conserved Domains (1) summary
      pfam02368
      Location:1079 → 1152
      Big_2; Bacterial Ig-like domain (group 2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      13316235..13420322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447797.1 → XP_047303753.1  nuclear pore membrane glycoprotein 210 isoform X5

    2. XM_047447795.1 → XP_047303751.1  nuclear pore membrane glycoprotein 210 isoform X3

    3. XM_047447796.1 → XP_047303752.1  nuclear pore membrane glycoprotein 210 isoform X4

    4. XM_011533538.3 → XP_011531840.1  nuclear pore membrane glycoprotein 210 isoform X2

    5. XM_005264994.4 → XP_005265051.1  nuclear pore membrane glycoprotein 210 isoform X1

    6. XM_047447798.1 → XP_047303754.1  nuclear pore membrane glycoprotein 210 isoform X6

    RNA

    1. XR_007095651.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      13316581..13420679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345851.1 → XP_054201826.1  nuclear pore membrane glycoprotein 210 isoform X5

    2. XM_054345849.1 → XP_054201824.1  nuclear pore membrane glycoprotein 210 isoform X3

    3. XM_054345850.1 → XP_054201825.1  nuclear pore membrane glycoprotein 210 isoform X4

    4. XM_054345848.1 → XP_054201823.1  nuclear pore membrane glycoprotein 210 isoform X1

    5. XM_054345852.1 → XP_054201827.1  nuclear pore membrane glycoprotein 210 isoform X6

    RNA

    1. XR_008486679.1 RNA Sequence

    2. XR_008486680.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEM1.3 GenPept UniProtKB/Swiss-Prot:Q8TEM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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