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    CTTN cortactin [ Homo sapiens (human) ]

    Gene ID: 2017, updated on 3-Dec-2024

    Summary

    Official Symbol
    CTTNprovided by HGNC
    Official Full Name
    cortactinprovided by HGNC
    Primary source
    HGNC:HGNC:3338
    See related
    Ensembl:ENSG00000085733 MIM:164765; AllianceGenome:HGNC:3338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMS1
    Summary
    This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CTTN in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (70398529..70436575)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (70418951..70456993)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70244635..70282681)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369373 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70175478-70175614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70187532-70188110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70188111-70188688 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70230466-70230972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:70235067-70235838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70235839-70236608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70237380-70238149 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70242965-70243153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3704 Neighboring gene Sharpr-MPRA regulatory region 1776 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70250285-70250464 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70261331-70261532 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:70265651-70266850 Neighboring gene CTTN divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70289993-70290826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70343973-70344473 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70346781-70346940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70351607-70352106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70364325-70364826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70369495-70370452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70370453-70371408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70371409-70372366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70373323-70374279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70384621-70385240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70385241-70385858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70390839-70391673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70392509-70393343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70393780-70394730 Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70397475-70397990 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:70399135-70400334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70404151-70404881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70403420-70404150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70422686-70423186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70423187-70423687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70425215-70425716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70428716-70429218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429219-70429720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429721-70430223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70430775-70431315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70457727-70458490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70464553-70465368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70465369-70466183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70483308-70484149 Neighboring gene Sharpr-MPRA regulatory region 3810 Neighboring gene SHANK2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70508534-70509208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70509209-70509883 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70516085-70516612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70519247-70519774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70526489-70527252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70527253-70528017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70533609-70534130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70534131-70534652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70555908-70556529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70559535-70560424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70560938-70561770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70563993-70564502 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70565347-70565550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70585495-70586046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70586047-70586598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70591157-70591852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70591853-70592548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70592549-70593244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70614429-70614930 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:70634290-70635489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70680550-70681124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70681125-70681698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70681699-70682272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70686259-70686758 Neighboring gene SHANK2 antisense RNA 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated cortactin (CTTN) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables profilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lamellipodium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in substrate-dependent cell migration, cell extension IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion HDA PubMed 
    colocalizes_with growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    src substrate cortactin
    Names
    amplaxin
    ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
    epididymis secretory sperm binding protein
    oncogene EMS1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029881.1 RefSeqGene

      Range
      5024..43070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184740.2NP_001171669.1  src substrate cortactin isoform c

      See identical proteins and their annotated locations for NP_001171669.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses different splice sites in the 3' coding region, which changes reading frame and the termination stop codon, compared to variant 1. The resulting protein (isoform c) has a longer and distinct C-terminus when it is compared to isoform a.
      Source sequence(s)
      AA325227, BC033889, DA716772
      Consensus CDS
      CCDS53676.1
      UniProtKB/Swiss-Prot
      Q14247
      Related
      ENSP00000365745.3, ENST00000376561.7
      Conserved Domains (3) summary
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:288363
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17036
      Location:459501
      SH3; Src Homology 3 domain superfamily
    2. NM_005231.4NP_005222.2  src substrate cortactin isoform a

      See identical proteins and their annotated locations for NP_005222.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript.
      Source sequence(s)
      AK222613, AK291097, BC008799, DA716772
      Consensus CDS
      CCDS41680.1
      UniProtKB/Swiss-Prot
      Q14247, Q8N707, Q96H99
      UniProtKB/TrEMBL
      A0A384MDY8
      Related
      ENSP00000301843.8, ENST00000301843.13
      Conserved Domains (3) summary
      cd11959
      Location:496548
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:325400
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    3. NM_138565.3NP_612632.1  src substrate cortactin isoform b

      See identical proteins and their annotated locations for NP_612632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1. The resulting protein (isoform b) has the same N- and C- termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AK222613, BC008799, DA716772
      Consensus CDS
      CCDS8197.1
      UniProtKB/TrEMBL
      A0A384MDY8
      Related
      ENSP00000317189.4, ENST00000346329.7
      Conserved Domains (4) summary
      cd11959
      Location:459511
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      pfam15927
      Location:322359
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
      cl26557
      Location:310445
      RNase_E_G; Ribonuclease E/G family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      70398529..70436575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718447.4XP_006718510.1  src substrate cortactin isoform X1

      UniProtKB/TrEMBL
      A0A384MDY8
      Conserved Domains (3) summary
      cd11959
      Location:422474
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:157192
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:251326
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    2. XM_006718448.5XP_006718511.1  src substrate cortactin isoform X2

      Conserved Domains (1) summary
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
    3. XM_017017312.3XP_016872801.1  src substrate cortactin isoform X3

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160005.1 Reference GRCh38.p14 PATCHES

      Range
      159817..197863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332474.1XP_054188449.1  src substrate cortactin isoform X1

      UniProtKB/TrEMBL
      A0A384MDY8
    2. XM_054332475.1XP_054188450.1  src substrate cortactin isoform X2

    3. XM_054332476.1XP_054188451.1  src substrate cortactin isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      70418951..70456993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367962.1XP_054223937.1  src substrate cortactin isoform X1

      UniProtKB/TrEMBL
      A0A384MDY8
    2. XM_054367963.1XP_054223938.1  src substrate cortactin isoform X2

    3. XM_054367964.1XP_054223939.1  src substrate cortactin isoform X3