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    BRMS1 BRMS1 transcriptional repressor and anoikis regulator [ Homo sapiens (human) ]

    Gene ID: 25855, updated on 27-Nov-2024

    Summary

    Official Symbol
    BRMS1provided by HGNC
    Official Full Name
    BRMS1 transcriptional repressor and anoikis regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:17262
    See related
    Ensembl:ENSG00000174744 MIM:606259; AllianceGenome:HGNC:17262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BRMS1 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66337339..66345104, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66330994..66338767, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66104810..66112575, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66083264-66083960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66086517-66087018 Neighboring gene CD248 molecule Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66087019-66087518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66093768-66094517 Neighboring gene Ras and Rab interactor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66104385-66105239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66112315-66112865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3589 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene tRNA-Ser (anticodon GCT) 3-1 Neighboring gene B4GAT1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564A063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    breast cancer metastasis-suppressor 1
    Names
    breast cancer metastasis suppressor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024957.2NP_001020128.1  breast cancer metastasis-suppressor 1 isoform 2

      See identical proteins and their annotated locations for NP_001020128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon which results in the use of a downstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AP001107, BM312965, CB130346, CB529276
      Consensus CDS
      CCDS44654.1
      UniProtKB/TrEMBL
      E9PJF5, G5E9I4
      Related
      ENSP00000396052.2, ENST00000425825.6
      Conserved Domains (1) summary
      pfam08598
      Location:60177
      Sds3; Sds3-like
    2. NM_015399.4NP_056214.1  breast cancer metastasis-suppressor 1 isoform 1

      See identical proteins and their annotated locations for NP_056214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest and more abundant transcript and encodes isoform (1).
      Source sequence(s)
      AP001107, BU734281, CB130346
      Consensus CDS
      CCDS8135.1
      UniProtKB/Swiss-Prot
      Q6IAI2, Q9HCU9
      UniProtKB/TrEMBL
      E9PJF5
      Related
      ENSP00000353042.3, ENST00000359957.8
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66337339..66345104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448426.2XP_024304194.1  breast cancer metastasis-suppressor 1 isoform X2

      UniProtKB/TrEMBL
      E9PJF5
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like
    2. XM_024448425.2XP_024304193.1  breast cancer metastasis-suppressor 1 isoform X1

      UniProtKB/TrEMBL
      H0YCF7
      Related
      ENSP00000431510.1, ENST00000524699.5
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66330994..66338767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368347.1XP_054224322.1  breast cancer metastasis-suppressor 1 isoform X2

    2. XM_054368346.1XP_054224321.1  breast cancer metastasis-suppressor 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024958.1: Suppressed sequence

      Description
      NM_001024958.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.