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    RXFP3 relaxin family peptide receptor 3 [ Homo sapiens (human) ]

    Gene ID: 51289, updated on 9-Dec-2024

    Summary

    Official Symbol
    RXFP3provided by HGNC
    Official Full Name
    relaxin family peptide receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:24883
    See related
    Ensembl:ENSG00000182631 MIM:609445; AllianceGenome:HGNC:24883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SALPR; RLN3R1; RXFPR3; GPCR135
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Involved in positive regulation of cytokinesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RXFP3 in Genome Data Viewer
    Location:
    5p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (33936386..33938918)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (34058309..34060841)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33936491..33939023)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22456 Neighboring gene ST3GAL5 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:33788320-33789519 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33850007-33850508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891377-33891878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891879-33892378 Neighboring gene RNA, U6 small nuclear 923, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33931143-33931648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944338-33944838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944839-33945339 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33978101-33978993 Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene solute carrier family 45 member 2 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene alpha-methylacyl-CoA racemase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    relaxin-3 receptor 1
    Names
    G-protein coupled receptor GPCR135
    G-protein coupled receptor SALPR
    RLN3 receptor 1
    g protein-coupled receptor SALPR
    relaxin/insulin like family peptide receptor 3
    somatostatin and angiotensin-like peptide receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016568.3NP_057652.1  relaxin-3 receptor 1

      See identical proteins and their annotated locations for NP_057652.1

      Status: VALIDATED

      Source sequence(s)
      AC139777, BC113438, D88437
      Consensus CDS
      CCDS3900.1
      UniProtKB/Swiss-Prot
      Q14DA5, Q9NSD7
      UniProtKB/TrEMBL
      Q502V2
      Related
      ENSP00000328708.3, ENST00000330120.5
      Conserved Domains (1) summary
      pfam00001
      Location:98389
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      33936386..33938918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187551.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      137708..140240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      34058309..34060841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)