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    ARL15 ARF like GTPase 15 [ Homo sapiens (human) ]

    Gene ID: 54622, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARL15provided by HGNC
    Official Full Name
    ARF like GTPase 15provided by HGNC
    Primary source
    HGNC:HGNC:25945
    See related
    Ensembl:ENSG00000185305 AllianceGenome:HGNC:25945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARFRP2
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 11.3), gall bladder (RPKM 8.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARL15 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (53883942..54310573, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (54711445..55138165, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (53179772..53606403, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16007 Neighboring gene MPRA-validated peak5241 silencer Neighboring gene long intergenic non-protein coding RNA 2105 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:53149739-53150938 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:53157616-53157824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:53178032-53179231 Neighboring gene argininosuccinate synthetase 1 pseudogene 9 Neighboring gene RNA, U6 small nuclear 272, pseudogene Neighboring gene microRNA 581 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:53313399-53314173 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53314174-53314947 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:53315686-53316592 Neighboring gene RNA, 7SL, cytoplasmic 801, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr5:53476360-53476866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:53592529-53593029 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53600502-53601165 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1314 Neighboring gene GATA motif-containing MPRA enhancer 36 Neighboring gene long intergenic non-protein coding RNA 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22549 Neighboring gene ribosomal protein L37 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:53735813-53736314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22550 Neighboring gene heat shock protein family B (small) member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application. Saini M, et al. Curr Protein Pept Sci, 2024. PMID 37718516
    2. Association of the ARL15 rs6450176 SNP and serum lipid levels in the Jing and Han populations. Sun JQ, et al. Int J Clin Exp Pathol, 2015. PMID 26722494, Free PMC Article
    3. Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts. Kashyap S, et al. Clin Exp Rheumatol, 2018 Jul-Aug. PMID 29465355
    4. Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis. Sharma A, et al. J Biomol Struct Dyn, 2022 Jul. PMID 33356902
    5. ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs. Zolotarov Y, et al. Cell Mol Life Sci, 2021 Jul. PMID 34089346, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application.
      Title: ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application.
    2. Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer.
      Title: Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer.
    3. Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis.
      Title: Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis.
    4. Magnesium homeostasis is regulated by ARL15 through N-glycosylations of CNNMs.
      Title: ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs.
    5. Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis.
      Title: Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis.
    6. ARL15 plays a role in adipocyte differentiation and adiponectin secretion
      Title: The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
    7. ARL15 expression in rheumatoid arthritis synovial fibroblasts (RASF) play likely role in inflammation and metabolic syndromes through a TNF independent pathway.
      Title: Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
    8. The ARL15 and HLA-DMA gene polymorphisms are associated with RA risk in Northwestern Han Chinese population.
      Title: [Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].
    9. These findings indicated that there may be a racial/ethnic- and/or sex-specific association of the ARL15 rs6450176 single nucleotide polymorphism and serum lipid levels.
      Title: Association of the ARL15 rs6450176 SNP and serum lipid levels in the Jing and Han populations.
    10. The SNPs in ADP-ribosylation factor-like protein 15 (ARL15) and the T-cadherin (CDH13) genes did not exhibit significant association with individual metabolic traits in the T2DM and NDM groups.
      Title: Association study of ARL15 and CDH13 with T2DM in a Han Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians.
    EBI GWAS Catalog
    A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20051

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 15
    Names
    ADP ribosylation factor like GTPase 15
    ADP-ribosylation factor-like 15
    ADP-ribosylation factor-related protein 2
    ARF-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019087.3 → NP_061960.1  ADP-ribosylation factor-like protein 15

      See identical proteins and their annotated locations for NP_061960.1

      Status: VALIDATED

      Source sequence(s)
      AC025175, AK000058
      Consensus CDS
      CCDS54850.1
      UniProtKB/Swiss-Prot
      Q6IAD0, Q9NXU5
      UniProtKB/TrEMBL
      A8K4C1
      Related
      ENSP00000433427.1, ENST00000504924.6
      Conserved Domains (1) summary
      cl21455
      Location:34 → 193
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      53883942..54310573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543500.3 → XP_011541802.1  ADP-ribosylation factor-like protein 15 isoform X3

      UniProtKB/TrEMBL
      A8K4C1
      Conserved Domains (2) summary
      cd04162
      Location:53 → 212
      Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
      COG1100
      Location:50 → 174
      Gem1; GTPase SAR1 family domain [General function prediction only]

    2. XM_017009598.2 → XP_016865087.1  ADP-ribosylation factor-like protein 15 isoform X4

      UniProtKB/TrEMBL
      A8K4C1
      Conserved Domains (1) summary
      cd04162
      Location:36 → 195
      Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase

    3. XM_047417335.1 → XP_047273291.1  ADP-ribosylation factor-like protein 15 isoform X4

      UniProtKB/TrEMBL
      A8K4C1

    4. XM_011543499.3 → XP_011541801.1  ADP-ribosylation factor-like protein 15 isoform X2

      Conserved Domains (2) summary
      cd04162
      Location:76 → 235
      Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
      COG1100
      Location:73 → 197
      Gem1; GTPase SAR1 family domain [General function prediction only]

    5. XM_047417336.1 → XP_047273292.1  ADP-ribosylation factor-like protein 15 isoform X4

      UniProtKB/TrEMBL
      A8K4C1

    6. XM_011543498.3 → XP_011541800.1  ADP-ribosylation factor-like protein 15 isoform X1

      Conserved Domains (2) summary
      cd04162
      Location:95 → 254
      Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
      COG1100
      Location:92 → 216
      Gem1; GTPase SAR1 family domain [General function prediction only]

    7. XM_047417338.1 → XP_047273294.1  ADP-ribosylation factor-like protein 15 isoform X5

      UniProtKB/TrEMBL
      A0A0B4J222

    8. XM_047417340.1 → XP_047273296.1  ADP-ribosylation factor-like protein 15 isoform X7

      UniProtKB/TrEMBL
      A0A0B4J222

    9. XM_047417339.1 → XP_047273295.1  ADP-ribosylation factor-like protein 15 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J222
      Related
      ENSP00000432680.1, ENST00000507646.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      54711445..55138165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352857.1 → XP_054208832.1  ADP-ribosylation factor-like protein 15 isoform X2

    2. XM_054352858.1 → XP_054208833.1  ADP-ribosylation factor-like protein 15 isoform X3

      UniProtKB/TrEMBL
      A8K4C1

    3. XM_054352860.1 → XP_054208835.1  ADP-ribosylation factor-like protein 15 isoform X4

      UniProtKB/TrEMBL
      A8K4C1

    4. XM_054352859.1 → XP_054208834.1  ADP-ribosylation factor-like protein 15 isoform X4

      UniProtKB/TrEMBL
      A8K4C1

    5. XM_054352856.1 → XP_054208831.1  ADP-ribosylation factor-like protein 15 isoform X1

    6. XM_054352861.1 → XP_054208836.1  ADP-ribosylation factor-like protein 15 isoform X7

      UniProtKB/TrEMBL
      A0A0B4J222
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXU5.1 GenPept UniProtKB/Swiss-Prot:Q9NXU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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