U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RARA retinoic acid receptor alpha [ Homo sapiens (human) ]

    Gene ID: 5914, updated on 3-Dec-2024

    Summary

    Official Symbol
    RARAprovided by HGNC
    Official Full Name
    retinoic acid receptor alphaprovided by HGNC
    Primary source
    HGNC:HGNC:9864
    See related
    Ensembl:ENSG00000131759 MIM:180240; AllianceGenome:HGNC:9864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAR; NR1B1; RARalpha
    Summary
    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in lung (RPKM 10.4), spleen (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RARA in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40309180..40357643)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41172682..41221155)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38465432..38513895)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family member 2 Neighboring gene RNY4 pseudogene 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38437298-38438234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38438235-38439169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38443891-38444698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38447656-38448242 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:38452145-38452660 Neighboring gene cell division cycle 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38464859-38465744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38465745-38466628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38468218-38468718 Neighboring gene uncharacterized LOC105371934 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38473742-38473951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38477303-38477887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38497666-38498244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498280-38498830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498831-38499380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38500481-38501031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38501032-38501581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38501582-38502132 Neighboring gene RARA antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38509021-38509532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8487 Neighboring gene Sharpr-MPRA regulatory region 13940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8490 Neighboring gene GJD3 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 54 Neighboring gene gap junction protein delta 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription PubMed
    matrix gag HIV-1 MA upregulates RARA gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha-actinin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heterocyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinoic acid-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Sertoli cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in face development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glandular epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in growth plate cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in limb development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-13 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-5 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinoic acid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trachea cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    retinoic acid receptor alpha
    Names
    PML-DDX5-RARA fusion
    PML-DDX5-RARA fusion protein
    RAR-alpha
    nuclear receptor subfamily 1 group B member 1
    nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
    retinoic acid receptor, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027701.1 RefSeqGene

      Range
      5010..53473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1070

    mRNA and Protein(s)

    1. NM_000964.4NP_000955.1  retinoic acid receptor alpha isoform 1

      See identical proteins and their annotated locations for NP_000955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC008727, BM992549, DA061829, X06614
      Consensus CDS
      CCDS11366.1
      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
      Related
      ENSP00000254066.5, ENST00000254066.10
      Conserved Domains (2) summary
      cd06937
      Location:186416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    2. NM_001024809.4NP_001019980.1  retinoic acid receptor alpha isoform 2

      See identical proteins and their annotated locations for NP_001019980.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) reflects the use of an alternate promoter and has a distinct 5' exon, compared to transcript variant 1. Translation is predicted to initiate from this alternate exon, and the resulting protein (isoform 2) has a shorter and a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC080112, BC071733, BM838347, BM992549
      Consensus CDS
      CCDS42317.1
      UniProtKB/TrEMBL
      A8K840, F1D8N9
      Related
      ENSP00000377643.3, ENST00000394081.7
      Conserved Domains (2) summary
      cd06937
      Location:181411
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:77161
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    3. NM_001145301.3NP_001138773.1  retinoic acid receptor alpha isoform 1

      See identical proteins and their annotated locations for NP_001138773.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) reflects the use of an alternate promoter and contains a different 5' UTR segment, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK292205, BG394590, BM992549, X06614
      Consensus CDS
      CCDS11366.1
      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
      Related
      ENSP00000377649.2, ENST00000394089.6
      Conserved Domains (2) summary
      cd06937
      Location:186416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    4. NM_001145302.3NP_001138774.1  retinoic acid receptor alpha isoform 4

      See identical proteins and their annotated locations for NP_001138774.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) reflects the use of an alternate promoter and contains a different 5' UTR segment. This variant also lacks two in-frame coding exons, compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.
      Source sequence(s)
      AC080112, BG394590, BM992549, FJ487576
      Consensus CDS
      CCDS45671.1
      UniProtKB/Swiss-Prot
      P10276
      Related
      ENSP00000389993.3, ENST00000425707.7
      Conserved Domains (1) summary
      cd06937
      Location:89319
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40309180..40357643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525095.2XP_011523397.1  retinoic acid receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_011523397.1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
      Conserved Domains (2) summary
      cd06937
      Location:186416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    2. XM_047436507.1XP_047292463.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    3. XM_005257554.2XP_005257611.1  retinoic acid receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_005257611.1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
      Conserved Domains (2) summary
      cd06937
      Location:186416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    4. XM_047436508.1XP_047292464.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    5. XM_047436506.1XP_047292462.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    6. XM_005257553.2XP_005257610.1  retinoic acid receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_005257610.1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
      Conserved Domains (2) summary
      cd06937
      Location:186416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    7. XM_011525096.2XP_011523398.1  retinoic acid receptor alpha isoform X3

      UniProtKB/TrEMBL
      A8K840
      Conserved Domains (2) summary
      cd06937
      Location:128358
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:24108
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    8. XM_005257552.6XP_005257609.1  retinoic acid receptor alpha isoform X2

      See identical proteins and their annotated locations for XP_005257609.1

      UniProtKB/TrEMBL
      A8MUP8, B3KUX3
      Related
      ENSP00000377648.3, ENST00000394086.7
      Conserved Domains (2) summary
      cd06937
      Location:202432
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:98182
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41172682..41221155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316839.1XP_054172814.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    2. XM_054316840.1XP_054172815.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    3. XM_054316838.1XP_054172813.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    4. XM_054316841.1XP_054172816.1  retinoic acid receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      B8Y636, P10276, P78456, Q9NQS0
      UniProtKB/TrEMBL
      A8K840, Q6I9R7
    5. XM_054316844.1XP_054172819.1  retinoic acid receptor alpha isoform X2

      UniProtKB/TrEMBL
      A8MUP8, B3KUX3
    6. XM_054316842.1XP_054172817.1  retinoic acid receptor alpha isoform X4

    7. XM_054316843.1XP_054172818.1  retinoic acid receptor alpha isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033603.1: Suppressed sequence

      Description
      NM_001033603.1: This RefSeq was permanently suppressed because the 3'UTR is not supported and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.