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    NEUROG3 neurogenin 3 [ Homo sapiens (human) ]

    Gene ID: 50674, updated on 9-Dec-2024

    Summary

    Official Symbol
    NEUROG3provided by HGNC
    Official Full Name
    neurogenin 3provided by HGNC
    Primary source
    HGNC:HGNC:13806
    See related
    Ensembl:ENSG00000122859 MIM:604882; AllianceGenome:HGNC:13806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ngn3; Atoh5; NGN-3; Math4B; bHLHa7
    Summary
    The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
    Expression
    Biased expression in duodenum (RPKM 1.5), small intestine (RPKM 0.6) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NEUROG3 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69571485..69573422, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (70439446..70441420, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71331454..71333178, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:71284727-71284879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71287440-71288387 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene NANOG hESC enhancer GRCh37_chr10:71329867-71330445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71331344-71331971 Neighboring gene uncharacterized LOC101929021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2436 Neighboring gene NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer Neighboring gene MT-ATP6 pseudogene 23 Neighboring gene MT-CO2 pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neurogenin 3 (NEUROG3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hindbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peripheral nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transdifferentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neurogenin-3
    Names
    class A basic helix-loop-helix protein 7
    protein atonal homolog 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021321.1 RefSeqGene

      Range
      5033..6757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020999.4NP_066279.2  neurogenin-3

      See identical proteins and their annotated locations for NP_066279.2

      Status: REVIEWED

      Source sequence(s)
      AK313952, AL450311, BC069098
      Consensus CDS
      CCDS31212.1
      UniProtKB/Swiss-Prot
      Q5VVI0, Q6DJX6, Q9BY24, Q9Y4Z2
      Related
      ENSP00000242462.4, ENST00000242462.5
      Conserved Domains (1) summary
      cd00083
      Location:81140
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      69571485..69573422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016280.2XP_016871769.1  neurogenin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q5VVI0, Q6DJX6, Q9BY24, Q9Y4Z2
      Conserved Domains (1) summary
      cd00083
      Location:81140
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      70439446..70441420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365966.1XP_054221941.1  neurogenin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q5VVI0, Q6DJX6, Q9BY24, Q9Y4Z2