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    SLURP1 secreted LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 57152, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLURP1provided by HGNC
    Official Full Name
    secreted LY6/PLAUR domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18746
    See related
    Ensembl:ENSG00000126233 MIM:606119; AllianceGenome:HGNC:18746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT
    Summary
    The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward esophagus (RPKM 167.7) See more
    Orthologs
    NEW
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    Genomic context

    See SLURP1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142740949..142742406, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143884338..143885795, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143822367..143823824, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member K Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19605 Neighboring gene thioesterase superfamily member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143819807-143820373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19607 Neighboring gene LY6/PLAUR domain containing 2 Neighboring gene uncharacterized LOC124902033 Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene secreted LY6/PLAUR domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    secreted Ly-6/uPAR-related protein 1
    Names
    ARS(component B)-81/S
    SLURP-1
    anti-neoplastic urinary protein
    lymphocyte antigen 6-like secreted
    secreted Ly6/uPAR related protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011494.1 RefSeqGene

      Range
      5006..6463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020427.3NP_065160.1  secreted Ly-6/uPAR-related protein 1 precursor

      See identical proteins and their annotated locations for NP_065160.1

      Status: REVIEWED

      Source sequence(s)
      AC083841
      Consensus CDS
      CCDS6387.1
      UniProtKB/Swiss-Prot
      P55000, Q53YJ6, Q6PUA6, Q92483
      Related
      ENSP00000246515.1, ENST00000246515.2
      Conserved Domains (1) summary
      cd00117
      Location:23101
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      142740949..142742406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      143884338..143885795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)