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    STK35 serine/threonine kinase 35 [ Homo sapiens (human) ]

    Gene ID: 140901, updated on 9-Dec-2024

    Summary

    Official Symbol
    STK35provided by HGNC
    Official Full Name
    serine/threonine kinase 35provided by HGNC
    Primary source
    HGNC:HGNC:16254
    See related
    Ensembl:ENSG00000125834 MIM:609370; AllianceGenome:HGNC:16254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLIK1; STK35L1
    Summary
    The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STK35 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (2101827..2148555)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2131852..2178591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2082473..2129201)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PDYN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1974244-1975074 Neighboring gene Sharpr-MPRA regulatory region 7514 Neighboring gene prodynorphin Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075323-2075824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075825-2076324 Neighboring gene ribosomal protein L7 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2083234-2084202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12600 Neighboring gene uncharacterized LOC124900458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2126343-2127006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2131168-2131684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2131685-2132200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2143700-2144200 Neighboring gene uncharacterized LOC124904859 Neighboring gene uncharacterized LOC105372502

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 35
    Names
    CLIK-1
    CLP-36 interacting kinase
    CLP-36-interacting kinase 1
    PDLIM1-interacting kinase 1
    serine threonine kinase 35 long form
    serine/threonine-protein kinase 35 L1
    NP_543026.2
    XP_011527476.2
    XP_054179044.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080836.4NP_543026.2  serine/threonine-protein kinase 35

      See identical proteins and their annotated locations for NP_543026.2

      Status: REVIEWED

      Source sequence(s)
      AL359916, BC140884, GQ281297
      Consensus CDS
      CCDS13024.2
      UniProtKB/Swiss-Prot
      B2RBM3, C7ENV8, Q2NKW6, Q5T3R1, Q5T3R2, Q8TDR2, Q96AB4, Q9BZ06
      Related
      ENSP00000370891.3, ENST00000381482.8
      Conserved Domains (2) summary
      smart00220
      Location:202523
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13977
      Location:201529
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      2101827..2148555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529174.4XP_011527476.2  serine/threonine-protein kinase 35 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      2131852..2178591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323069.1XP_054179044.1  serine/threonine-protein kinase 35 isoform X1