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    ZSCAN26 zinc finger and SCAN domain containing 26 [ Homo sapiens (human) ]

    Gene ID: 7741, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZSCAN26provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 26provided by HGNC
    Primary source
    HGNC:HGNC:12978
    See related
    Ensembl:ENSG00000197062 MIM:616474; AllianceGenome:HGNC:12978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREZBP; ZNF187; SRE-ZBP
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 7.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZSCAN26 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28267143..28278204)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28138885..28149946)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28234921..28245981)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17043 Neighboring gene NFKB activating protein like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28234963-28235527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17044 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28249721-28249897 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28251848-28252055 Neighboring gene piggyBac transposable element derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28278749-28279250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28279251-28279750 Neighboring gene SMIM15 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2815

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 26
    Names
    zinc finger protein 187

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001023560.4NP_001018854.2  zinc finger and SCAN domain-containing protein 26 isoform a

      See identical proteins and their annotated locations for NP_001018854.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK095948, AL526328, BC013951
      UniProtKB/TrEMBL
      A0A024RCN4
      Related
      ENSP00000481707.1, ENST00000421553.7
      Conserved Domains (6) summary
      smart00431
      Location:52158
      SCAN; leucine rich region
      COG5048
      Location:290469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:283305
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47135
      SCAN; SCAN domain
      pfam13465
      Location:297322
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001111039.3NP_001104509.1  zinc finger and SCAN domain-containing protein 26 isoform b

      See identical proteins and their annotated locations for NP_001104509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK095948, AK301081, BC013951, DA884554
      Consensus CDS
      CCDS78119.1
      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17
      Related
      ENSP00000485228.1, ENST00000623276.3
      Conserved Domains (6) summary
      smart00431
      Location:52157
      SCAN; leucine rich region
      COG5048
      Location:289468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284304
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47135
      SCAN; SCAN domain
      pfam13465
      Location:296321
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001287421.2NP_001274350.1  zinc finger and SCAN domain-containing protein 26 isoform c

      See identical proteins and their annotated locations for NP_001274350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
      Source sequence(s)
      AK301081, AL021997, AL832741, DA341149
      Consensus CDS
      CCDS75414.1
      UniProtKB/TrEMBL
      A0A087X2F1
      Related
      ENSP00000479314.1, ENST00000614088.1
      Conserved Domains (3) summary
      COG5048
      Location:174334
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:150170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162187
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001287422.2NP_001274351.1  zinc finger and SCAN domain-containing protein 26 isoform d

      See identical proteins and their annotated locations for NP_001274351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) lacks two exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant a. It encodes isoform d, which is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK095948, AL832741, DA528922
      Consensus CDS
      CCDS75415.1
      UniProtKB/TrEMBL
      B4DMT1
      Related
      ENSP00000478769.1, ENST00000611552.2
      Conserved Domains (3) summary
      COG5048
      Location:100260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:7696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:88113
      zf-H2C2_2; Zinc-finger double domain
    5. NM_152736.6NP_689949.3  zinc finger and SCAN domain-containing protein 26 isoform c

      See identical proteins and their annotated locations for NP_689949.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
      Source sequence(s)
      BC013951, DB262147
      Consensus CDS
      CCDS75414.1
      UniProtKB/TrEMBL
      A0A087X2F1
      Related
      ENSP00000484931.1, ENST00000316606.10
      Conserved Domains (3) summary
      COG5048
      Location:174334
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:150170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162187
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28267143..28278204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419314.1XP_047275270.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    2. XM_011514862.3XP_011513164.1  zinc finger and SCAN domain-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_011513164.1

      UniProtKB/TrEMBL
      A0A024RCN4
      Related
      ENSP00000484018.1, ENST00000619937.4
      Conserved Domains (6) summary
      smart00431
      Location:52158
      SCAN; leucine rich region
      COG5048
      Location:290469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:283305
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47135
      SCAN; SCAN domain
      pfam13465
      Location:297322
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017011264.2XP_016866753.1  zinc finger and SCAN domain-containing protein 26 isoform X2

      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17
      Conserved Domains (6) summary
      smart00431
      Location:52157
      SCAN; leucine rich region
      COG5048
      Location:289468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284304
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47135
      SCAN; SCAN domain
      pfam13465
      Location:296321
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011514864.2XP_011513166.1  zinc finger and SCAN domain-containing protein 26 isoform X3

      See identical proteins and their annotated locations for XP_011513166.1

      Conserved Domains (3) summary
      COG5048
      Location:261440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:23129
      SCAN; SCAN oligomerization domain
    5. XM_047419312.1XP_047275268.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    6. XM_047419313.1XP_047275269.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    7. XM_024446538.2XP_024302306.1  zinc finger and SCAN domain-containing protein 26 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:261440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:23129
      SCAN; SCAN oligomerization domain
    8. XM_047419311.1XP_047275267.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      28138885..28149946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356349.1XP_054212324.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    2. XM_054356342.1XP_054212317.1  zinc finger and SCAN domain-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A024RCN4
    3. XM_054356343.1XP_054212318.1  zinc finger and SCAN domain-containing protein 26 isoform X2

      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17
    4. XM_054356345.1XP_054212320.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    5. XM_054356347.1XP_054212322.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    6. XM_054356348.1XP_054212323.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    7. XM_054356344.1XP_054212319.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    8. XM_054356346.1XP_054212321.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007151.1: Suppressed sequence

      Description
      NM_007151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate when translated from the upstream AUG.