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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023212.3 RefSeqGene
- Range
-
4868..239476
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_014244.5 → NP_055059.2 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform 1 preproprotein
See identical proteins and their annotated locations for NP_055059.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AC008544, AC010216, AC109479, AJ003125, CA445758, DA928965
- Consensus CDS
-
CCDS4444.1
- UniProtKB/Swiss-Prot
-
O95450
- UniProtKB/TrEMBL
-
A0A1B0GTY3
- Related
- ENSP00000251582.7, ENST00000251582.12
- Conserved Domains (6) summary
-
- smart00209
Location:564 → 616
- TSP1; Thrombospondin type 1 repeats
- cd04273
Location:266 → 467
- ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
- pfam05986
Location:723 → 837
- ADAM_spacer1; ADAM-TS Spacer 1
- pfam01562
Location:91 → 212
- Pep_M12B_propep; Reprolysin family propeptide
- pfam17771
Location:482 → 551
- ADAM_CR_2; ADAM cysteine-rich domain
- pfam19030
Location:979 → 1028
- TSP1_ADAMTS; Thrombospondin type 1 domain
-
NM_021599.4 → NP_067610.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform 2 precursor
See identical proteins and their annotated locations for NP_067610.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks several exons and includes an alternate exon in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1. Isoform 2 lacks the TSP type-1 domains compared to isoform 1 but may undergo proteolytic processing similar to isoform 1.
- Source sequence(s)
-
AC010216, AC109479, AK308213, BM512469
- Consensus CDS
-
CCDS34311.1
- UniProtKB/Swiss-Prot
-
O95450
- Related
- ENSP00000274609.5, ENST00000274609.5
- Conserved Domains (3) summary
-
- cd04273
Location:266 → 467
- ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
- pfam01421
Location:268 → 470
- Reprolysin; Reprolysin (M12B) family zinc metalloprotease
- pfam01562
Location:100 → 211
- Pep_M12B_propep; Reprolysin family propeptide
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000005.10 Reference GRCh38.p14 Primary Assembly
- Range
-
179110853..179345461 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047417895.1 → XP_047273851.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X1
- UniProtKB/TrEMBL
-
A0A1B0GTY3
-
XM_047417896.1 → XP_047273852.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X2
Reference GRCh38.p14 PATCHES
Genomic
-
NW_016107298.1 Reference GRCh38.p14 PATCHES
- Range
-
20229..110168 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060929.1 Alternate T2T-CHM13v2.0
- Range
-
179664045..179898855 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054353826.1 → XP_054209801.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X1
- UniProtKB/TrEMBL
-
A0A1B0GTY3
-
XM_054353827.1 → XP_054209802.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X2