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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001271608.2 → NP_001258537.1 LIM and SH3 domain protein 1 isoform b
See identical proteins and their annotated locations for NP_001258537.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which results in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
- Source sequence(s)
-
AK294704, AK295522, AK309933, BC007560, BQ961916, X82456
- Consensus CDS
-
CCDS62164.1
- UniProtKB/Swiss-Prot
-
Q14847
- UniProtKB/TrEMBL
-
B4DIC4
- Related
- ENSP00000401048.2, ENST00000433206.6
- Conserved Domains (2) summary
-
- smart00227
Location:42 → 72
- NEBU; The Nebulin repeat is present also in Las1
- cd11934
Location:147 → 205
- SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
-
NM_006148.4 → NP_006139.1 LIM and SH3 domain protein 1 isoform a
See identical proteins and their annotated locations for NP_006139.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (a).
- Source sequence(s)
-
BC007560, DC333179, X82456
- Consensus CDS
-
CCDS11331.1
- UniProtKB/Swiss-Prot
- B4DGQ0, Q14847, Q96ED2, Q96IG0
- UniProtKB/TrEMBL
-
A8K1D2
- Related
- ENSP00000325240.6, ENST00000318008.11
- Conserved Domains (3) summary
-
- smart00227
Location:98 → 128
- NEBU; The Nebulin repeat is present also in Las1
- cd09447
Location:5 → 57
- LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
- cd11934
Location:203 → 261
- SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
RNA
-
NR_073384.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
- Source sequence(s)
-
AK095958, AK309933, BC007560, DC333179, X82456
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
38870058..38921770
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047435965.1 → XP_047291921.1 LIM and SH3 domain protein 1 isoform X1
- UniProtKB/TrEMBL
-
A8K1D2
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
39733108..39784846
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)