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    COX7B cytochrome c oxidase subunit 7B [ Homo sapiens (human) ]

    Gene ID: 1349, updated on 9-Dec-2024

    Summary

    Official Symbol
    COX7Bprovided by HGNC
    Official Full Name
    cytochrome c oxidase subunit 7Bprovided by HGNC
    Primary source
    HGNC:HGNC:2291
    See related
    Ensembl:ENSG00000131174 MIM:300885; AllianceGenome:HGNC:2291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APLCC; LSDMCA2
    Summary
    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in heart (RPKM 234.2), kidney (RPKM 174.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See COX7B in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (77899468..77907376)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76334526..76342432)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77154965..77162873)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene magnesium transporter 1 Neighboring gene RNA, 7SL, cytoplasmic 460, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29782 Neighboring gene ATPase copper transporting alpha Neighboring gene C4orf46 pseudogene 2 Neighboring gene phosphoglycerate mutase family member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 7B, mitochondrial
    Names
    cytochrome c oxidase polypeptide VIIb
    cytochrome c oxidase subunit VIIb
    cytochrome-c oxidase chain VIIb
    NP_001857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033027.2 RefSeqGene

      Range
      5005..12913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1250

    mRNA and Protein(s)

    1. NM_001866.3NP_001857.1  cytochrome c oxidase subunit 7B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001857.1

      Status: REVIEWED

      Source sequence(s)
      AL356235, Z14244
      Consensus CDS
      CCDS14437.1
      UniProtKB/Swiss-Prot
      B2R4M3, P24311, Q6ICR1
      Related
      ENSP00000497474.1, ENST00000650309.2
      Conserved Domains (1) summary
      pfam05392
      Location:179
      COX7B; Cytochrome C oxidase chain VIIB

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      77899468..77907376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      76334526..76342432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)