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    HLA-F major histocompatibility complex, class I, F [ Homo sapiens (human) ]

    Gene ID: 3134, updated on 3-Dec-2024

    Summary

    Official Symbol
    HLA-Fprovided by HGNC
    Official Full Name
    major histocompatibility complex, class I, Fprovided by HGNC
    Primary source
    HGNC:HGNC:4963
    See related
    Ensembl:ENSG00000204642 MIM:143110; AllianceGenome:HGNC:4963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLAF; CDA12; HLA-5.4; HLA-CDA12
    Summary
    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 31.0), lymph node (RPKM 20.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HLA-F in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29723434..29738532)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29594785..29612450)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29691211..29695073)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1 Neighboring gene HLA complex group 4 pseudogene 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29691770-29692604 Neighboring gene HLA-F antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 1 Neighboring gene MHC class I polypeptide-related sequence E (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29716125-29716632 Neighboring gene HLA complex group 9 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.
    EBI GWAS Catalog
    Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    env Conformational changes in HIV-1 gp120, including an enhanced expression of the V3 loop of gp120 and of epitopes that are exposed upon CD4 binding, are consistent with the formation of a multimolecular complex between HLA class I and gp120/160 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules is processed by angiotensin-1 converting enzyme (ACE) prior to T cell stimulation by the peptide p18 PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded PubMed
    nef Double (W13A/V16R) and triple (W13A/V16R/M20A) substitution mutants of HIV-1 Nef fail to downregulate MHC-I PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
    nef HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin PubMed
    nef HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity PubMed
    nef Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes PubMed
    nef Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery PubMed
    nef A methionine residue at amino acid 20 in the alpha-helix domain is required for the ability of HIV-1 Nef to downregulate MHC-I expression but not for the downregulation of CD4 PubMed
    nef Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface PubMed
    nef Amino acid residue Y320 in the MHC-I cytoplasmic domain and residues E62-65 and P78 in HIV-1 Nef are required for interaction with the mu subunit of AP-1 PubMed
    nef MHC-I is found in the Rab7(+) vesicles and is targeted for degradation via the activity of the Nef-interacting protein, beta-COP PubMed
    Tat tat HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses PubMed
    tat HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance PubMed
    Vpu vpu HLA class I-associated immune responses have minor effects on Vpu variability, suggesting that Vpu conformation and function are preserved through many possible combinations of primary and secondary polymorphisms PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TAP1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-2-microglobulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class Ib IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of T cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of natural killer cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of natural killer cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of natural killer cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of MHC class Ib protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    HLA class I histocompatibility antigen, alpha chain F
    Names
    HLA F antigen
    MHC class I antigen F
    leukocyte antigen F
    non-classical MHC class I antigen
    nonclassical MHC class I antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012009.2 RefSeqGene

      Range
      5002..8864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098478.2NP_001091948.1  HLA class I histocompatibility antigen, alpha chain F isoform 3 precursor

      See identical proteins and their annotated locations for NP_001091948.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding exon and uses an alternate 3' exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY253271, BC062991, BM798587, CA436948
      Consensus CDS
      CCDS43439.1
      UniProtKB/TrEMBL
      A0A0G2JNV5
      Related
      ENSP00000397376.2, ENST00000434407.6
      Conserved Domains (1) summary
      pfam00129
      Location:22200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. NM_001098479.2NP_001091949.1  HLA class I histocompatibility antigen, alpha chain F isoform 1 precursor

      See identical proteins and their annotated locations for NP_001091949.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      BC009260, BM798587, CB528356, CD369507, CT002787
      Consensus CDS
      CCDS43437.1
      UniProtKB/TrEMBL
      A0A140T9B7, Q5JZ48
      Related
      ENSP00000259951.6, ENST00000259951.12
      Conserved Domains (2) summary
      cd07698
      Location:204296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    3. NM_018950.3NP_061823.2  HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor

      See identical proteins and their annotated locations for NP_061823.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY253270, BM798587, CA436948, CD365590
      Consensus CDS
      CCDS43438.1
      UniProtKB/Swiss-Prot
      P30511, Q5JQI8, Q5JQJ1, Q5SPT5, Q860R0, Q8MGQ1, Q8WLP5, Q95HC0, Q9TP68
      UniProtKB/TrEMBL
      A0A346MPT4, Q5JZ47
      Related
      ENSP00000334263.4, ENST00000334668.8
      Conserved Domains (2) summary
      pfam00129
      Location:22200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21023
      Location:201298
      IgC1_MHC_Ia_HLA-F; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) F; member of the C1-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29723434..29738532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010813.2XP_016866302.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A346MPT4
    2. XM_047418720.1XP_047274676.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    3. XM_011514564.2XP_011512866.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      See identical proteins and their annotated locations for XP_011512866.1

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
      Conserved Domains (2) summary
      cd07698
      Location:204296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    4. XM_047418718.1XP_047274674.1  HLA class I histocompatibility antigen, alpha chain F isoform X3

      UniProtKB/TrEMBL
      B4DQ99
    5. XM_047418719.1XP_047274675.1  HLA class I histocompatibility antigen, alpha chain F isoform X1

      UniProtKB/TrEMBL
      B4DQ99
    6. XM_017010810.1XP_016866299.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_017010812.2XP_016866301.1  HLA class I histocompatibility antigen, alpha chain F isoform X6

      UniProtKB/TrEMBL
      A0A140T9B7
    8. XM_047418721.1XP_047274677.1  HLA class I histocompatibility antigen, alpha chain F isoform X7

    RNA

    1. XR_001743374.2 RNA Sequence

    2. XR_001743373.2 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1206571..1225171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329815.1XP_054185790.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2, A0A3G2C0L7, D0EV57, Q6DU20, Q6DU28
    2. XM_054329813.1XP_054185788.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    3. XM_054329814.1XP_054185789.1  HLA class I histocompatibility antigen, alpha chain F isoform X11

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    4. XM_054329816.1XP_054185791.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    5. XM_054329817.1XP_054185792.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    6. XM_054329807.1XP_054185782.1  HLA class I histocompatibility antigen, alpha chain F isoform X3

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_054329809.1XP_054185784.1  HLA class I histocompatibility antigen, alpha chain F isoform X1

      UniProtKB/TrEMBL
      B4DQ99
    8. XM_054329808.1XP_054185783.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    9. XM_054329811.1XP_054185786.1  HLA class I histocompatibility antigen, alpha chain F isoform X10

      UniProtKB/TrEMBL
      B4DQ99
    10. XM_054329812.1XP_054185787.1  HLA class I histocompatibility antigen, alpha chain F isoform X6

      UniProtKB/TrEMBL
      A0A140T9B7
    11. XM_054329810.1XP_054185785.1  HLA class I histocompatibility antigen, alpha chain F isoform X9

      UniProtKB/TrEMBL
      A0A140T9B7
    12. XM_054329818.1XP_054185793.1  HLA class I histocompatibility antigen, alpha chain F isoform X7

    RNA

    1. XR_008485660.1 RNA Sequence

    2. XR_008485661.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      985769..1004398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330301.1XP_054186276.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2, A0A3G2C0L7, D0EV57, Q6DU20, Q6DU28
    2. XM_054330302.1XP_054186277.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    3. XM_054330299.1XP_054186274.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    4. XM_054330300.1XP_054186275.1  HLA class I histocompatibility antigen, alpha chain F isoform X14

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    5. XM_054330303.1XP_054186278.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    6. XM_054330295.1XP_054186270.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_054330297.1XP_054186272.1  HLA class I histocompatibility antigen, alpha chain F isoform X13

      UniProtKB/TrEMBL
      B4DQ99
    8. XM_054330298.1XP_054186273.1  HLA class I histocompatibility antigen, alpha chain F isoform X6

      UniProtKB/TrEMBL
      A0A140T9B7
    9. XM_054330296.1XP_054186271.1  HLA class I histocompatibility antigen, alpha chain F isoform X12

      UniProtKB/TrEMBL
      A0A140T9B7
    10. XM_054330304.1XP_054186279.1  HLA class I histocompatibility antigen, alpha chain F isoform X15

    RNA

    1. XR_008485693.1 RNA Sequence

    2. XR_008485694.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      985516..1003989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330596.1XP_054186571.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2, A0A3G2C0L7, D0EV57, Q6DU20, Q6DU28
    2. XM_054330594.1XP_054186569.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    3. XM_054330595.1XP_054186570.1  HLA class I histocompatibility antigen, alpha chain F isoform X18

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    4. XM_054330597.1XP_054186572.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    5. XM_054330598.1XP_054186573.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    6. XM_054330590.1XP_054186565.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_054330592.1XP_054186567.1  HLA class I histocompatibility antigen, alpha chain F isoform X17

      UniProtKB/TrEMBL
      B4DQ99
    8. XM_054330593.1XP_054186568.1  HLA class I histocompatibility antigen, alpha chain F isoform X6

      UniProtKB/TrEMBL
      A0A140T9B7
    9. XM_054330591.1XP_054186566.1  HLA class I histocompatibility antigen, alpha chain F isoform X16

      UniProtKB/TrEMBL
      A0A140T9B7
    10. XM_054330599.1XP_054186574.1  HLA class I histocompatibility antigen, alpha chain F isoform X19

    RNA

    1. XR_008485699.1 RNA Sequence

    2. XR_008485700.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      986160..988296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      985785..1004368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331068.1XP_054187043.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2, A0A3G2C0L7, D0EV57, Q6DU20, Q6DU28
    2. XM_054331066.1XP_054187041.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    3. XM_054331067.1XP_054187042.1  HLA class I histocompatibility antigen, alpha chain F isoform X22

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    4. XM_054331069.1XP_054187044.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    5. XM_054331070.1XP_054187045.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    6. XM_054331062.1XP_054187037.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_054331064.1XP_054187039.1  HLA class I histocompatibility antigen, alpha chain F isoform X21

      UniProtKB/TrEMBL
      B4DQ99
    8. XM_054331065.1XP_054187040.1  HLA class I histocompatibility antigen, alpha chain F isoform X6

      UniProtKB/TrEMBL
      A0A140T9B7
    9. XM_054331063.1XP_054187038.1  HLA class I histocompatibility antigen, alpha chain F isoform X20

      UniProtKB/TrEMBL
      A0A140T9B7
    10. XM_054331071.1XP_054187046.1  HLA class I histocompatibility antigen, alpha chain F isoform X23

    RNA

    1. XR_008485710.1 RNA Sequence

    2. XR_008485711.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1029693..1047565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331334.1XP_054187309.1  HLA class I histocompatibility antigen, alpha chain F isoform X27

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    2. XM_054331335.1XP_054187310.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    3. XM_054331337.1XP_054187312.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    4. XM_054331332.1XP_054187307.1  HLA class I histocompatibility antigen, alpha chain F isoform X25

      UniProtKB/TrEMBL
      B4DQ99
    5. XM_054331333.1XP_054187308.1  HLA class I histocompatibility antigen, alpha chain F isoform X26

      UniProtKB/TrEMBL
      A0A140T9B7
    6. XM_054331331.1XP_054187306.1  HLA class I histocompatibility antigen, alpha chain F isoform X24

      UniProtKB/TrEMBL
      A0A140T9B7
    7. XM_054331336.1XP_054187311.1  HLA class I histocompatibility antigen, alpha chain F isoform X28

      UniProtKB/TrEMBL
      B7Z760

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29594785..29612450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355302.1XP_054211277.1  HLA class I histocompatibility antigen, alpha chain F isoform X3

      UniProtKB/TrEMBL
      B4DQ99
    2. XM_054355308.1XP_054211283.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2, A0A3G2C0L7, D0EV57, Q6DU20, Q6DU28
    3. XM_054355309.1XP_054211284.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    4. XM_054355304.1XP_054211279.1  HLA class I histocompatibility antigen, alpha chain F isoform X4

      UniProtKB/TrEMBL
      B4DQ99
    5. XM_054355303.1XP_054211278.1  HLA class I histocompatibility antigen, alpha chain F isoform X8

      UniProtKB/TrEMBL
      A0A0G2JH66, A0A140T9B7
    6. XM_054355305.1XP_054211280.1  HLA class I histocompatibility antigen, alpha chain F isoform X31

      UniProtKB/TrEMBL
      B4DQ99
    7. XM_054355306.1XP_054211281.1  HLA class I histocompatibility antigen, alpha chain F isoform X5

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    8. XM_054355307.1XP_054211282.1  HLA class I histocompatibility antigen, alpha chain F isoform X32

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    9. XM_054355301.1XP_054211276.1  HLA class I histocompatibility antigen, alpha chain F isoform X2

      UniProtKB/TrEMBL
      A0A140T8X0, A0A140T9V0
    10. XM_054355300.1XP_054211275.1  HLA class I histocompatibility antigen, alpha chain F isoform X30

      UniProtKB/TrEMBL
      A0A1V0E3T9, A0A1V0E3U0, A0A1V0E3U1, A0A1V0E3U3, A0A1V0E3V1, A0A1V0E3V5, A0A1V0E3W4, A0A1V0E3X2
    11. XM_054355298.1XP_054211273.1  HLA class I histocompatibility antigen, alpha chain F isoform X1

      UniProtKB/TrEMBL
      B4DQ99
    12. XM_054355299.1XP_054211274.1  HLA class I histocompatibility antigen, alpha chain F isoform X29

      UniProtKB/TrEMBL
      A0A140T9B7

    RNA

    1. XR_008487324.1 RNA Sequence

    2. XR_008487325.1 RNA Sequence

    3. XR_008487326.1 RNA Sequence