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    MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

    Gene ID: 4340, updated on 9-Dec-2024

    Summary

    Official Symbol
    MOGprovided by HGNC
    Official Full Name
    myelin oligodendrocyte glycoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:7197
    See related
    Ensembl:ENSG00000204655 MIM:159465; AllianceGenome:HGNC:7197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTN6; BTNL11; MOGIG2; NRCLP7
    Summary
    The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 52.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MOG in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29657092..29672365)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29531788..29547063)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624869..29640142)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29589456-29590006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29590007-29590556 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29592149-29592734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29596552-29597357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29598769-29599270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29610193-29610692 Neighboring gene SUMO2 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:29616349-29616969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29622853-29623353 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29627633-29628069 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29628451-29629365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29629366-29630280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29630281-29631194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634045-29634654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634655-29635264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29647510-29648030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29648031-29648552 Neighboring gene ZFP57 zinc finger protein Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29671001-29671115 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Narcolepsy 7
    MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26137

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    myelin-oligodendrocyte glycoprotein
    Names
    MOG AluA
    MOG AluB
    MOG Ig-AluB
    MOG alpha-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031873.1 RefSeqGene

      Range
      5112..20385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001008228.3NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18843, U64564
      Consensus CDS
      CCDS34369.1
      UniProtKB/TrEMBL
      A0A0G2JHA9
      Related
      ENSP00000379932.3, ENST00000396704.7
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    2. NM_001008229.3NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, AY566853, DA139582, DA140757, U64564
      Consensus CDS
      CCDS34368.1
      UniProtKB/TrEMBL
      A0A0G2JI49
      Related
      ENSP00000366088.4, ENST00000376891.8
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    3. NM_001170418.2NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AL119259, AY566847, DA139582, DA140757, U64564
      Consensus CDS
      CCDS54977.1
      UniProtKB/TrEMBL
      E9PG44
      Related
      ENSP00000420350.1, ENST00000490427.5
    4. NM_001363610.2NP_001350539.1  myelin-oligodendrocyte glycoprotein isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents the longest transcript and encodes the longest isoform (10).
      Source sequence(s)
      AL645936, BC035938
      Consensus CDS
      CCDS87379.1
      UniProtKB/TrEMBL
      A0A0G2JHM8
      Related
      ENSP00000366091.4, ENST00000376894.8
      Conserved Domains (1) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    5. NM_002433.5NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

      See identical proteins and their annotated locations for NP_002424.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta1) encodes the beta1 isoform, also known as isoform 1.
      Source sequence(s)
      AL119259, AY566852, DA139582, DA140757, U64564
      Consensus CDS
      CCDS4667.1
      UniProtKB/TrEMBL
      Q5SSB8
      Related
      ENSP00000366095.3, ENST00000376898.7
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    6. NM_206809.4NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

      See identical proteins and their annotated locations for NP_996532.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U64564, X74511
      Consensus CDS
      CCDS34370.1
      UniProtKB/Swiss-Prot
      A6NDR4, A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5, O00713, O00714, O00715, Q13054, Q13055, Q14855, Q16653, Q29ZN8, Q56UY0, Q5JNX7, Q5JNY1, Q5JNY2, Q5JNY4, Q5SSB5, Q5SSB6, Q5STL9, Q5STM0, Q5STM1, Q5STM2, Q5STM5, Q5SUK5, Q5SUK7, Q5SUK8, Q5SUK9, Q5SUL0, Q5SUL1, Q8IYG5, Q92891, Q92892, Q92893, Q92894, Q92895, Q93053, Q96KU9, Q96KV0, Q96KV1, Q99605
      UniProtKB/TrEMBL
      Q5SSB8
      Related
      ENSP00000366115.3, ENST00000376917.8
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    7. NM_206810.4NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18803, U64564
      Consensus CDS
      CCDS34367.1
      UniProtKB/TrEMBL
      A0A0G2JIU9
      Related
      ENSP00000379929.2, ENST00000396701.6
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    8. NM_206811.4NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18840, U64564
      Consensus CDS
      CCDS34366.1
      UniProtKB/TrEMBL
      A0A0G2JKI0
      Related
      ENSP00000417405.1, ENST00000494692.5
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    9. NM_206812.4NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18799, U64564
      Consensus CDS
      CCDS47394.1
      UniProtKB/TrEMBL
      A0A0G2JI49
      Related
      ENSP00000410866.2, ENST00000431798.6
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    10. NM_206814.6NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AK308949, AL119259, DA139582, DA140757, U64564
      Consensus CDS
      CCDS47395.2
      UniProtKB/TrEMBL
      A0A0G2JHB7
      Related
      ENSP00000366085.2, ENST00000376888.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29657092..29672365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      922801..938073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1143564..1158838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      922637..937911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      922209..937479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      922473..937739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      922592..937866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      966127..981397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29531788..29547063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_206813.4: Suppressed sequence

      Description
      NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.