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    BNIP3 BCL2 interacting protein 3 [ Homo sapiens (human) ]

    Gene ID: 664, updated on 9-Dec-2024

    Summary

    Official Symbol
    BNIP3provided by HGNC
    Official Full Name
    BCL2 interacting protein 3provided by HGNC
    Primary source
    HGNC:HGNC:1084
    See related
    Ensembl:ENSG00000176171 MIM:603293; AllianceGenome:HGNC:1084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIP3; HABON
    Summary
    This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BNIP3 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131967684..131981923, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (132907935..132922186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781188..133795427, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2948 Neighboring gene Sharpr-MPRA regulatory region 4393 Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:133747865-133749064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133758459-133759288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133761987-133762488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133785771-133786641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133794606-133795530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene uncharacterized LOC124902525 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) in human B cells PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
    vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables endoplasmic reticulum-autophagosome adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitochondrion autophagosome adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy of mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cobalt ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in granzyme-mediated programmed cell death signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial outer membrane permeabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to oxygen-glucose deprivation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
    Names
    BCL2/adenovirus E1B 19kDa interacting protein 3
    BCL2/adenovirus E1B interacting protein 3
    Hypoxia-Activated BNIP3 Overlapping Non-coding RNA
    nineteen kD interacting protein-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004052.4NP_004043.4  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

      Status: REVIEWED

      Source sequence(s)
      AL162274, AL732395
      Consensus CDS
      CCDS7663.3
      UniProtKB/Swiss-Prot
      O14620, Q12983, Q96GP0
      UniProtKB/TrEMBL
      Q53HF4
      Related
      ENSP00000357625.6, ENST00000368636.9
      Conserved Domains (1) summary
      pfam06553
      Location:9192
      BNIP3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      131967684..131981923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      132907935..132922186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)