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    NDUFB1 NADH:ubiquinone oxidoreductase subunit B1 [ Homo sapiens (human) ]

    Gene ID: 4707, updated on 27-Nov-2024

    Summary

    Official Symbol
    NDUFB1provided by HGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B1provided by HGNC
    Primary source
    HGNC:HGNC:7695
    See related
    Ensembl:ENSG00000183648 MIM:603837; AllianceGenome:HGNC:7695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MNLL; CI-MNLL; CI-SGDH
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial inner membrane and respiratory chain complex I. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 82.0), colon (RPKM 69.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NDUFB1 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92116123..92121706, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (86345661..86351545, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92582467..92588050, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92506403-92507190 Neighboring gene uncharacterized LOC124903363 Neighboring gene MPRA-validated peak2235 silencer Neighboring gene prothymosin alpha pseudogene 7 Neighboring gene MPRA-validated peak2236 silencer Neighboring gene ataxin 3 repeat instability region Neighboring gene ataxin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6031 Neighboring gene NANOG hESC enhancer GRCh37_chr14:92566141-92566677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92572215-92573149 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:92574354-92575164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92586481-92587470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8927 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:92624044-92624245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:92673090-92673696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:92673697-92674303 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:92719434-92719934 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:92719935-92720435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8928 Neighboring gene RNA, U6 small nuclear 366, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 (NDUFB1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
    NADH-ubiquinone oxidoreductase MNLL subunit
    complex I MNLL subunit
    complex I-MNLL

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004545.4NP_004536.3  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

      Status: VALIDATED

      Source sequence(s)
      BM052981, BX476462
      Consensus CDS
      CCDS9901.2
      UniProtKB/Swiss-Prot
      A0AV68, O75438
      Related
      ENSP00000475170.1, ENST00000605997.6
      Conserved Domains (1) summary
      pfam08040
      Location:158
      NADH_oxidored; MNLL subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      92116123..92121706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431421.1XP_047287377.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      A0AV68, O75438
      Related
      ENSP00000450776.1, ENST00000555441.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      86345661..86351545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)