TPX2 TPX2 microtubule nucleation factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: TPX2provided by HGNC
Official Full Name: TPX2 microtubule nucleation factorprovided by HGNC
Primary source: HGNC:HGNC:1249
See related: Ensembl:ENSG00000088325 MIM:605917; AllianceGenome:HGNC:1249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
Summary: Enables importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; nucleoplasm; and spindle. Is active in spindle. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (31739290..31801800)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (33463246..33526408)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30327093..30389603)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis.
Title: TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis.
Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors.
Title: Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors.
TPX2 influences the regulation of macrophage polarization via the NF-kappaB pathway in lung adenocarcinoma.
Title: TPX2 influences the regulation of macrophage polarization via the NF-κB pathway in lung adenocarcinoma.
miRNA-27b-3p/TPX2 Axis Regulates Clear Cell Renal Cell Carcinoma Cell Proliferation, Invasion and Migration.
Title: miRNA-27b-3p/TPX2 Axis Regulates Clear Cell Renal Cell Carcinoma Cell Proliferation, Invasion and Migration.
TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells with gain of 20q11.21.
Title: TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells with gain of 20q11.21.
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer.
Title: TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer.
miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration.
Title: miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration.
TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability.
Title: TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability.
KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
Title: KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells.
Title: TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16281 (e-PCR)
- UniSTS:16552

TPX2_9293 (e-PCR)
- UniSTS:468156

RH79783 (e-PCR)
- UniSTS:92133

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables importin-alpha family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
is_active_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: targeting protein for Xklp2

Names: TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog; differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in cancerous and noncancerous lung cells 2; differentially expressed in lung cells; hepatocellular carcinoma-associated antigen 519; hepatocellular carcinoma-associated antigen 90; preferentially expressed in colorectal cancer; protein fls353; restricted expression proliferation associated protein 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012112.5 → NP_036244.2 targeting protein for Xklp2

See identical proteins and their annotated locations for NP_036244.2

Status: VALIDATED

Source sequence(s)

AF098158, BC020207, CB960160

Consensus CDS

CCDS13190.1

UniProtKB/Swiss-Prot

Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1

UniProtKB/TrEMBL

B3KM90, Q643R0

Related

ENSP00000300403.6, ENST00000300403.11

Conserved Domains (3) summary

pfam09041
Location:1 → 68

Aurora-A_bind; Aurora-A binding

pfam06886
Location:660 → 740

TPX2; Targeting protein for Xklp2 (TPX2)

pfam12214
Location:367 → 489

TPX2_importin; Cell cycle regulated microtubule associated protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

31739290..31801800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528700.4 → XP_011527002.1 targeting protein for Xklp2 isoform X2

UniProtKB/TrEMBL

B3KM90

Conserved Domains (3) summary

pfam06886
Location:657 → 711

TPX2; Targeting protein for Xklp2 (TPX2)

pfam09041
Location:1 → 68

Aurora-A_bind; Aurora-A binding

pfam12214
Location:367 → 489

TPX2_importin; Cell cycle regulated microtubule associated protein
XM_011528699.3 → XP_011527001.1 targeting protein for Xklp2 isoform X1

See identical proteins and their annotated locations for XP_011527001.1

UniProtKB/Swiss-Prot

Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1

UniProtKB/TrEMBL

B3KM90, Q643R0

Conserved Domains (3) summary

pfam09041
Location:1 → 68

Aurora-A_bind; Aurora-A binding

pfam06886
Location:660 → 740

TPX2; Targeting protein for Xklp2 (TPX2)

pfam12214
Location:367 → 489

TPX2_importin; Cell cycle regulated microtubule associated protein
XM_047440018.1 → XP_047295974.1 targeting protein for Xklp2 isoform X2
XM_011528697.3 → XP_011526999.1 targeting protein for Xklp2 isoform X1

See identical proteins and their annotated locations for XP_011526999.1

UniProtKB/Swiss-Prot

Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1

UniProtKB/TrEMBL

B3KM90, Q643R0

Conserved Domains (3) summary

pfam09041
Location:1 → 68

Aurora-A_bind; Aurora-A binding

pfam06886
Location:660 → 740

TPX2; Targeting protein for Xklp2 (TPX2)

pfam12214
Location:367 → 489

TPX2_importin; Cell cycle regulated microtubule associated protein
XM_047440017.1 → XP_047295973.1 targeting protein for Xklp2 isoform X2