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    FEM1C fem-1 homolog C [ Homo sapiens (human) ]

    Gene ID: 56929, updated on 9-Dec-2024

    Summary

    Official Symbol
    FEM1Cprovided by HGNC
    Official Full Name
    fem-1 homolog Cprovided by HGNC
    Primary source
    HGNC:HGNC:16933
    See related
    Ensembl:ENSG00000145780 MIM:608767; AllianceGenome:HGNC:16933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FEM1A; EUROIMAGE686608; EUROIMAGE783647
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 24.9), testis (RPKM 9.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FEM1C in Genome Data Viewer
    Location:
    5q22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115520908..115544775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116033707..116057577, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114856605..114880472, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene COX assembly mitochondrial protein homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22932 Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22934 Neighboring gene TMED7-TICAM2 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16252 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114937526-114938048 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22936 Neighboring gene transmembrane p24 trafficking protein 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1785

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein fem-1 homolog C
    Names
    FEM1-gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020177.3NP_064562.1  protein fem-1 homolog C

      See identical proteins and their annotated locations for NP_064562.1

      Status: VALIDATED

      Source sequence(s)
      AB058688, AC008628, BC028369, W07603
      Consensus CDS
      CCDS4118.1
      UniProtKB/Swiss-Prot
      B2RE47, Q8N3V8, Q96JP0, Q9H704, Q9NPL6, Q9NPL9
      Related
      ENSP00000274457.3, ENST00000274457.5
      Conserved Domains (4) summary
      PHA02876
      Location:164568
      PHA02876; ankyrin repeat protein; Provisional
      COG0666
      Location:462599
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:118146
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:87178
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      115520908..115544775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      116033707..116057577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)